2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Article

ECETOC workshop on the biological significance of DNA adducts: Summary of follow-up from an Expert Panel Meeting

This workshop on the biological significance of DNA adducts included presentations of research results in the following areas: endogenous versus exogenous adduct levels; in vitro dose?response data on...
Article

Thresholds for Genotoxins and Their Application in Risk Assessment – Editorial

This special issue of Mutation Research presents discussion of, and new data establishing thresholds for genotoxic agents. The papers herein help to further challenge the common view that hazard equal...
Workshop Report

Workshop Report 15 – The Probabilistic Approaches for Marine Hazard Assessment

WR 15 : The Probabilistic Approaches for Marine Hazard Assessment | June 2009 In order to discuss the potential use of probabilistic techniques in marine environmental hazard assessment, a workshop...
Monograph

Monograph 038 – Toxicity of Engineered Nanomaterials

This special issue of Toxicology Letters presents new data on the toxicology of typical manufactured nanostructured materials. It includes results from on-going industry and academic projects on the (...
Workshop Report

Workshop Report 14 – Use of Markers for Improved Retrospective Exposure Assessment in Epidemiology Studies

WR 14 : Use of Markers for Improved Retrospective Exposure Assessment in Epidemiology Studies | February 2009 The workshop addressed the question of whether new analytical and molecular techniques...
Technical Report

TR 104 – Framework for the Integration of Human and Animal Data in Chemical Risk Assessment

TR 104 : Framework for the Integration of Human and Animal Data in Chemical Risk Assessment | January 2009 Human data form the most direct evidence for an association between health effects and exp...
Technical Report

TR 103 – Toxicity of Possible Impurities and By-products in Fluorocarbon Products

TR 103 : Toxicity of Possible Impurities and By-products in Fluorocarbon Products | December 2008 This report has been produced to accompany the ongoing series of reviews on fluorocarbons under the...
Document

DOC 046 – Potency Values from the Local Lymph Node Essay: Application to classification, labelling and risk assessment

DOC 046 : Potency Values from the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment | December 2008 In this ECETOC Document, the use of potency values derived fro...
Annual Report
Workshop Report

Workshop Report 13 – Counting the Costs and Benefits of Chemical Controls: Role of Environmental Risk Assessment in Socio-Economic Analysis

WR 13 : Counting the Costs and Benefits of Chemical Controls: Role of Environmental Risk Assessment in Socio-Economic Analysis | September 2008 This report arises from a workshop organised to exp...
Workshop Report

Workshop Report 12 – Workshop on Triggering and Waiving Criteria for the Extended One-Generation Reproduction Toxicity Study

WR 12 : Workshop on Triggering and Waiving Criteria for the Extended One-Generation Reproduction Toxicity Study | August 2008 Under the new chemicals legislation in Europe, REACH (EU, 2006), the tw...
Workshop Report

Workshop Report 11 – Workshop on the Application of ‘Omics in Toxicology and Ecotoxicology: Case Studies and Risk Assessment

WR 11 : Workshop on the Application of 'Omics in Toxicology and Ecotoxicology: Case Studies and Risk Assessment | July 2008 To review recent progress made on the application of 'omics technologies...
JACC

JACC Report 54 – Difluoromethane (Second Edition)

JACC 054 : Difluoromethane (HFC-32) CAS No. 75-10-5 (Second Edition) | June 2008 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It upd...
Document

DOC 045 – Triggering and Waiving Criteria for the Extended One-Generation Reproduction toxicity Study

DOC 045 : Triggering and Waiving Criteria for the Extended One-Generation Reproduction Toxicity Study | March 2008 The current ?gold standard' for the assessment of reproductive toxicity in safety ev...
Technical Report

TR 102 – Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals

TR 102 : Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals | December 2007 There is widespread regulatory and scientific interest in developin...
Workshop Report

Workshop Report 09 – Workshop on the Refinement of Mutagenicity / Genotoxicity Testing

WR 09 : Workshop on the Refinement of Mutagenicity / Genotoxicity Testing | November 2007 A workshop was convened by ECETOC to review current principles and methods of in vitro testing for mutageni...
Annual Report
Workshop Report

Workshop Report 10 – Workshop on Biodegradation and Persistence.

WR 10 : Workshop on Biodegradation and Persistence. | September 2007 This two-day workshop sponsored and organised by ECETOC and co-sponsored by the Environment Agency for England and Wales, took p...
JACC

JACC Report 53 – Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin vol.II

JACC 053 Vol II : Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin (CAS No. 74-90-8, 143-33-9, 151-50-8 and 75-86-5), Volumes I and II | November 2007 This report has been produc...

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