2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme! ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Article

Science based guidance for the assessment of endocrine disrupting properties of chemicals.

The European legislation on plant protection products (Regulation (EC) No. 1107/2009) and biocides (Directive 98/8/EC), as well as the regulation concerning chemicals (Regulation (EC) No. 1907/2006 ?R...
Article

Influence of indoor factors in dwellings on the development of childhood asthma

Asthma has become the most common, childhood chronic disease in the industrialized world, and it is also increasing in developing regions. There are huge differences in the prevalence of childhood ast...
Technical Report

TR 110 – Guidance on Assessment Factors to Derive a DNEL

TR 110 : Guidance on Assessment Factors to Derive a DNEL | Dec 2010 Executive Summary The European Regulation on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) req...
Technical Report

TR 109 – High information content technologies in support of read-across in chemical risk assessment

TR 109 : High information content technologies in support of read-across in chemical risk assessment | December 2010 Read-across exploits information on structurally related (similar) analogues to de...
Workshop Report

Workshop Report 20 – Workshop on Guidance on Assessment Factors to Derive a DNEL

WR 20 : Workshop on Guidance on Assessment Factors to Derive a DNEL | December 2010  Executive Summary Under REACH, chemicals produced in or imported into the EU, in amounts of = 10 tons/year, requ...
Article

Genotoxicity of Engineered Nanomaterials: Editorial

This special issue of Nanotoxicology reviews the biological significance of the available information on the genotoxicity of engineered nanomaterials (ENM). The papers herein discuss approaches to ide...
Article

Genotoxicity of Engineered Nanomaterials

This special issue of Nanotoxicology reviews the biological significance of the available information on the genotoxicity of engineered nanomaterials (ENM). The papers herein discuss approaches to ide...
Article

Potency Values From the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment

Link to the web page of this article: doi:10.1016/j.yrtph.2009.08.016 Please note that for copyright reasons the Secretariat cannot send a pdf version electronically. This needs to be downloaded fro...
Article

Overview of TTC Values – October 2010

Overview of TTC Values - October 2010...
Workshop Report

Workshop Report 19 – Omics in (Eco)toxicology: Case Studies and Risk Assessment

WR 19 : Omics in (Eco)toxicology: Case Studies and Risk Assessment | June 2010 review the progress made on the application of ?omics technologies to chemical safety and assess the potential impact...
Annual Report
Article
Article

Guidance for the classification of carcinogens under the globally harmonised system of classification and labelling of chemicals (GHS)

Link to the web page of this article: doi:10.3109/10408440903384717 Please note that for copyright reasons the Secretariat cannot send a pdf version electronically. This needs to be downloaded from...
Workshop Report

Workshop Report 17 – Significance of Bound Residues in Environmental Risk Assessment

WR 17 : Significance of Bound Residues in Environmental Risk Assessment | February 2010 Report from the Workshop of 14-15 October 2009, Brussels (Published February 2010) Thirty-eight leading ex...
Technical Report

TR 108 EMBK – Database for the Collation of Existing Marine Biodegradation Data and its Use in Environmental Risk Assessment

TR 108 EMBK : Database for the Collation of Existing Marine Biodegradation Data and its Use in Environmental Risk Assessment | December 2009 The primary focus for the Biodegradation kinetics Task For...
Technical Report

TR 108 – Collation of Existing Marine Biodegradation Data and its Use in Environmental Risk Assessment [Includes EMBK Database]

TR 108: Collation of Existing Marine Biodegradation Data and its Use in Environmental Risk Assessment | December 2009 The primary focus for the Biodegradation kinetics Task Force was to prepare a hig...
Technical Report

TR 107 – Addendum to ECETOC Targeted Risk Assessment Technical Report No. 93

TR 107 : Addendum to ECETOC Targeted Risk Assessment Technical Report No. 93 | December 2009 The ECETOC targeted risk assessment (TRA) Task Force reported in 2004 (Technical Report No. 93), and launc...
Workshop Report

Workshop Report 18 – Enhancement of the Scientific Process and Transparency of Observational Epidemiology Studies

WR 18 : Enhancement of the Scientific Process and Transparency of Observational Epidemiology Studies | November 2009 Background: Observational epidemiology studies have greatly contributed to...
Technical Report

TR 106 – Guidance on Identifying Endocrine Disrupting Effects

TR 106 : Guidance on Identifying Endocrine Disrupting Effects | June 2009 Recent revision of the European directive on plant protection products (Directive 91/414/EEC) and new regulations concerning...
Technical Report

TR 105 – Evaluation of Cardiac Sensitisation Test Methods

TR 105 : Evaluation of Cardiac Sensitisation Test Methods | October 2009 Cardiac sensitisation means that the normal heart rhythm becomes perturbed, for example, when high concentrations of some halo...
Workshop Report

Workshop Report 16 – Guidance on Interpreting Endocrine Disrupting Effects + Addendum

WR 16 and Addendum : Guidance on Interpreting Endocrine Disrupting Effects and Addendum | October 2009 Please note that this version of the report includes the addendum that was previously published...
Article

A Modular Approach to the Extended One-generation Reproduction Toxicity Study

This is the report of a combined initiative between the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) and the European Centre for the Validation of Alternative Methods (ECVAM)...

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