Publications
Article
Recognition of adverse and nonadverse effects in toxicity studies
One of the most important quantitative outputs from toxicity studies is identification of the highest exposure level (dose or concentration) that does not cause treatment related effects that could be...
Technical Report
TR 082 – Risk Assessment in Marine Environments
TR 082 : Risk Assessment in Marine Environments | December 2001
Within Europe, risk assessments for new and existing substances for the freshwater aquatic environment are based on the standardised pr...
Technical Report
TR 081 – Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy
TR 081 : Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy | November 2001
The industrial chemical monochloroacetic acid (MCAA) is used mainly in carboxylation reactions. It...
Monograph
Monograph 030 – Genetic Susceptibility to Environmental Toxicants
Mono 030 : Genetic Susceptibility to Environmental Toxicants | October 2001...
Annual Report
Technical Report
TR 080 – Aquatic Toxicity of Mixtures
TR 080 : Aquatic Toxicity of Mixtures | July 2001
The inherent toxicity of a substance to aquatic organisms is typically determined via single species laboratory tests. Results from these tests are u...
Technical Report
TR 079 – Exposure Factors Sourcebook for European Populations (with Focus on UK Data)
TR 079 : Exposure Factors Sourcebook for European Populations (with Focus on UK Data) | June 2001
Risk assessment includes elements of exposure, hazard, and dose-response. The exposure component is c...
Document
DOC 042 – Genomics, Transcript Profiling, Proteomics and Metabonomics (GTPM) An Introduction
DOC 042 : Genomics, transcript profiling (transcriptomics), proteomics and metabonomics (GTMP). An introduction | April 2001
Genomics, transcript profiling (transcriptomics), proteomics and metabon...
JACC
JACC Report 40 – Peracetic Acid and its Equilibrium Solutions
JACC 040 : Peracetic Acid (CAS No. 79-21-0) and its Equilibrium Solutions | January 2001
This report has been produced as part of the Joint Assessment of Commodity Chemicals (JACC) programme. It pr...
Article
Scientific analysis of the proposed uses of T25 dose descriptor in chemical carcinogen regulation. An ECETOC Workshop Overview.
The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving...
Article
Skin sensitisation: New perspectives and recommendations
Various methodological aspects of skin sensitisation testing have been explored, particularly in the context of animal welfare considerations and reliability and sensitivity of test methods. Recommend...
Article
Skin sensitisation testing in potency and risk assessment
The purpose of this article is to review, and make recommendations for, the use of relevant skin sensitization test methods, for the purposes of determination of relative potency and the threshold dos...
Article
Monitoring, modelling and environmental exposure assessment of industrial chemicals in the aquatic environment
Monitoring and laboratory data play integral roles alongside fate and exposure models in comprehensive risk assessments. The principle in the European Union Technical Guidance Documents for risk asses...
Article
Ecological risk assessment of endocrine disrupters
The European Centre for Ecotoxicology and Toxicology of Chemicals proposes a tiered approach for the ecological risk assessment of endocrine disruptors, integrating exposure and hazard (effects) chara...
Document
DOC 041 – Persistent Organic Pollutants (POPs) Response to UNEP/INC/CEG-I Annex 1
DOC 041 : Persistent Organic Pollutants (POPs) Response to UNEP/INC/CEG-I Annex 1 | January 2000
An ECETOC Task Force started to work on the definition of scientific criteria for POP identification...
Document
DOC 040 – Comments on Recommendation from Scientific Commitee on Occupational Exposure Limits for 1,3-Butadiene
DOC 040 : Comment on Recommendation from Scientific Committee on Occupational Exposure Limits for 1,3-Butadiene | October 2000
The present document reviews the Recommendation on Occupational Exposu...
Annual Report
Monograph
Monograph 029 – Skin Sensitisation Testing for the Purpose of Hazard Indentification and Risk Assessment
Mono 029 : Skin Sensitisation Testing for the Purpose of Hazard Indentification and Risk Assessment | September 2000
The first step in any toxicological evaluation is the accurate identification of...
Article
Removal of linear alkylbenzene sulfonate from a small Yorkshire stream: Contribution to GREAT-ER project # 7
An in-stream removal experiment has been carried out in Red Beck, a small stream which receives effluent from Shibden Head Sewage Treatment Works. This trickling filter works serves a purely domestic...
Monograph
Monograph 028 – Threshold-Mediated Mutagens — Mutation Research Special Issue
Mono 028 : Threshold-Mediated Mutagens -- Mutation Research Special Issue| January 2000
The symposium on 'dose response and threshold effects in mutagenesis' co-sponsored by the European Environmen...
Technical Report
TR 078 – Skin Sensitisation Testing: Methodological Considerations
TR 078 : Skin Sensitisation Testing: Methodological Considerations | December 1999
Skin sensitisation testing was considered last by ECETOC in Monograph No.14 (1990). Since then a revised OECD guidel...
JACC
JACC Report 39 – Tetrachloroethylene
JACC 039 : Tetrachloroethylene (CAS No. 127-18-4) | December 1999
This report presents a critical evaluation of the toxicology and ecotoxicology of tetrachloroethylene (CAS No. 127-18-4). It has be...