2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme! ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Document

DOC 037 – EC Classification of Eye Irritancy

DOC 037 : EC Classification of Eye Irritancy | December 1997...
Annual Report
Monograph

Monograph 027 – Aneuploidy

Mono 027 : Aneuploidy | August 1997 Aneuploidy plays a significant role in adverse human health conditions including birth defects, pregnancy wastage and cancer. Although there is clear evidence of...
Special Report

Special Report 13 – Occupational Exposure Limits for Hydrocarbon Solvents

SR 13 : Occupational Exposure Limits for Hydrocarbon Solvents | August 1997...
Document

DOC 036 – Comments on OECD Draft Detail Review Paper: Appraisal of Test Methods for Sex-Hormone Disrupting Chemicals

DOC 036 : Comments on OECD Draft Detailed Review Paper: Appraisal of Test Methods for Sex-Hormone Disrupting Chemicals | August 1997...
Technical Report

TR 072 – Methyl tert-Butyl Ether (MTBE) Health Risk Characterisation

TR 072 : Methyl tert-Butyl Ether (MTBE) Health Risk Characterisation | June 1997 Use Methyl tert-butyl ether (MTBE) is a colourless flammable liquid with a distinctive ethereal odour.  It is used a...
Article

Integration of bioaccumulation in an environmental risk assessment

The potential of a substance to bioaccumulate in the aquatic environment into an organism depends particularly on its lipophilicity and its metabolism within the organism. Bioaccumulation is an expos...
Document

DOC 035 – Exposure Assessment in the Context of the EU Technical Guidance Documents on Risk Assessment of Substances

DOC 035 : Exposure Assessment in the Context of the EU Technical Guidance Documents on Risk Assessment of Substances | May 1997...
Special Report

Special Report 12 – 1,3-Butadiene OEL Criteria Document (Second Edition)

SR 12 : 1,3-Butadiene OEL Criteria Document (2nd Edition) (CAS No. 106-99-0) | January 1997  ...
Special Report

Special Report 11 – Ecotoxicology of Some Inorganic Borates

SR 11 : Ecotoxicology of some Inorganic Borates | March 1997...
Document

DOC 034 – The Challenge Posed by Endocrine Disrupting Chemicals

DOC 034 : The Challenge Posed by Endocrine-disrupting Chemicals | February 1996  ...
Article

The challenge posed by endocrine-disrupting chemicals

Rapid regulatory developments in the area of environmental endocrine disruption present a series of potential problems that are identified and illustrated with examples taken from the recent literatur...
JACC

JACC Report 36 – n-Butyl Methacrylate Isobutyl Methacrylate

JACC 036 : n-Butyl Methacrylate; Isobutyl Methacrylate (CAS No.97-88-1) (CAS No.97-86-9) | December 1996...
Monograph

Monograph 026 – Aquatic Toxicity Testing of Sparingly Soluble, Volatile and Unstable Substances

Mono 026 : Aquatic Toxicity Testing of Sparingly Soluble, Volatile and Unstable Substances | September 1996 The objective of the Task Force was to review the scientific validity for the application o...
Technical Report

TR 071 – Inventory of Critical Reviews on Chemicals

TR 071 : Inventory of Critical Reviews on Chemicals | August 1996 The United Nations Environment Programme (UNEP), through its International Register of Potentially Toxic Chemicals (IRPTC), and the E...
Monograph

Monograph 025 – Practical Concepts for Dose Selection in Chronic Toxicity and Carcinogenicity Studies in Rodents

Mono 025 : Practical Concepts for Dose Selection in Chronic Toxicity and Carcinogenicity Studies in Rodents | February 1996...
Monograph

Monograph 024 – Risk Assessment for Carcinogens

Mono 024 : Risk Assessment for Carcinogens | July 1996...
Special Report

Special Report 10 – Hydrogen Peroxide OEL Criteria Document

SR 10 : Hydrogen Peroxide OEL Criteria Document (CAS No. 7722-84-1) | July 1996...
Document

DOC 033 – “Environmental Oestrogens” : A compendium of Test methods

DOC 033 : 'Environmental Oestrogens': A Compendium of Test Methods | July 1996 Against a background of increasing concern about the potential for natural and synthetic chemicals to affect reproduct...
Technical Report

TR 070 – Chronic Neurotoxicity of Solvents

TR 070 : Chronic Neurotoxicity of Solvents | February 1996 This review addresses the question whether a discrete specific neurological syndrome that is casually related to chronic low-level exposure...
Technical Report

TR 069 – Toxicology of Man-Made Organic Fibres

TR 069 : Toxicology of Man-Made Organic Fibres | April 1996 The established relationship between inhalation of asbestos fibres of respirable size and disease has led to a belief that all similarly si...
JACC

JACC Report 35 – Methacrylic Acid

JACC 035 : Methacrylic Acid (CAS No.79-41-4) | May 1996...
JACC

JACC Report 34 – Acrylic Acid

JACC 034 : Acrylic Acid (CAS No.79-10-7) | September 1995...
JACC

JACC Report 33 – 1,1-Dichloro-2,2,2-Trifluoroethane (HCFC-123)

JACC 033 : 1,1-Dichloro-2,2,2-Trifluoroethane (HCFC-123) (CAS No. 306-83-2) (Updated by JACC No. 47!) | February 1996...

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