2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why? Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
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Publications

JACC

JACC Report 33 – 1,1-Dichloro-2,2,2-Trifluoroethane (HCFC-123)

JACC 033 : 1,1-Dichloro-2,2,2-Trifluoroethane (HCFC-123) (CAS No. 306-83-2) (Updated by JACC No. 47!) | February 1996...
Document

DOC 032 – “Environmental Oestrogens”: Male Reproduction and Reproductive Development

DOC 032 : 'Environmental Oestrogens': Male Reproduction and Reproductive Development | January 1998 The paper was developed to review the currently available data relevant to the putative effects o...
Technical Report

TR 068 – Assessment Factors in Human Health Risk Assessment (Updated by TR No. 86)

TR 068 : Assessment Factors in Human Health Risk Assessment (Updated by TR No. 86) | August 1995 This Technical Report reviews the background to the role of 'Assessment Factors' (AFs) in Human Health...
Technical Report

TR 067 – The Role of Bioaccumulation in Environmental Risk Assessment: The Aquatic Environment and Related Food Webs

TR 067 : The Role of Bioaccumulation in Environmental Risk Assessment: The Aquatic Environment and Related Food Webs | October 1995 In this report the assumptions and equations used to determine bioc...
Technical Report

TR 066 – Skin Irritation and Corrosion: Reference Chemicals Data Bank

TR 066 : Skin Irritation and Corrosion: Reference Chemicals Data Bank | March 1995 Earlier ECETOC has published comprehensive listing of in vivo rabbit eye irritation data for 55 readily-available ch...
Technical Report

TR 065 – Formaldehyde and Human Cancer Risks

TR 065 : Formaldehyde and Human Cancer Risks | May 1995 Formaldehyde is a natural component in all mammalian cells and because of active enzymatic pathways is rapidly detoxified. Its use by man has b...
Technical Report

TR 064 – The Toxicology of Glycol Ethers and its Relevance to Man

TR 064 : The Toxicology of Glycol Ethers and its Relevance to Man | August 1995 A previous ECETOC review (1985) discussed the toxicological effects of ethylene and propylene glycol alkyl ethers and e...
Special Report

Special Report 09 – Styrene Criteria Document

SR 09 : Styrene Criteria Document | June 1995...
JACC

JACC Report 32 – Difluoromethane (HFC-32)

JACC 032 : Difluoromethane (HFC-32) CAS No. 75-10-5 | May 1995  ...
Article

Pathology considerations for, and subsequent risk assessment of, chemicals identified as immunosuppressive in routine toxicology

Several proposals have been made with the aim of assisting in the early identification of chemicals with immunotoxic potential. The Organisation for Economic Cooperation and Development is now likely...
JACC

JACC Report 31 – 1,1,1,2-Tetrafluoroethane (HFC-134a)

JACC 031 : 1,1,1,2-Tetrafluoroethane (HCFC-134a) (CAS No. 811-97-2) (Updated by JACC No. 50!) | February 1995...
JACC

JACC Report 30 – Methyl Methacrylate

JACC 030 : Methyl Methacrylate (CAS No.80-62-6) | February 1995...
Technical Report

TR 063 – Reproductive and General Toxicology of some Inorganic Borates and Risk Assessment for Human Beings

TR 063 : Reproductive and General Toxicology of some Inorganic Borates and Risk Assessment for Human Beings | February 1995 A review of the toxicology of some inorganic borates is provided together w...
Article

Polypropylene production and colorectal cancer: A review of the epidemiological evidence

Polypropylene has been produced for over 35 years and has a wide variety of applications including industrial uses, food packaging and many domestic uses. As a high-molecular-weight polymer, polypropy...
JACC

JACC Report 29 – 1,1-Dichloro-1-Fluoroethane (HCFC-141b)

JACC 029 : 1,1-Dichloro-1-Fluoroethane (HCFC-141b) CAS No 1717-00-6 | December 1994  ...
Monograph

Monograph 022 – Evaluation of Chemicals for Oculotoxicity

Mono 022: Evaluation of Chemicals for Oculotoxicity | November 1994...
Special Report

Special Report 08 – HAZCHEM A mathematical Model for Use in Risk Asessment

SR 08 : HAZCHEM: A Mathematical Model for Use in Risk Assessment of Substances | October 1984...
JACC

JACC Report 28 – Ethyl Acrylate

JACC 028 : Ethyl Acrylate (CAS No.140-88-5) | September 1994...
Technical Report

TR 062 – Ammonia Emissions to Air in Western Europe

TR 062 : Ammonia Emissions to Air in Western Europe | July 1994 Anthropogenic ammonia (NH3) emissions to the atmosphere in western Europe (EEC + EFTA countries) are estimated to be between...
JACC

JACC Report 27 – n-Butyl Acrylate

JACC 027 : n-Butyl Acrylate (CAS No.141-32-2) | August 1994...
Technical Report

TR 061 – Environmental Exposure Assessment

TR 061 : Environmental Exposure Assessment | September 1994 In ECETOC Technical Report No. 51 (ECETOC, 1993) a process for the Environmental Risk Assessment of Substances was described which is appli...
Monograph

Monograph 021 – Immunotoxicity: Hazard Identification and Risk Characterisation

Mono 021 : Immunotoxicity: Hazard Identification and Risk Characterisation | September 1994...
JACC

JACC Report 26 – Linear Polydimethylsiloxanes (viscosity 10-100,000 centistokes)

JACC 026 : Linear Polydimethylsiloxanes (CAS No.63148-62-9) | September 1994...

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