2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Workshop Report

Workshop Report 01 – Workshop on Availability, Interpretation and Use of Environmental Monitoring Data

WR 01 : Workshop on Availability, Interpretation and Use of Environmental Monitoring Data | December 2003 In recent years, there has been a growing emphasis on monitoring chemical substances in the...
Special Report

Special Report 17 – Risk Assessment Report for Existing Substances Methyl tertiary-Butyl Ether

SR 17 : Risk Assessment Report for Existing Substances Methyl tertiary-Butyl Ether | December 2003 Methyl tertiary-butyl ether (MTBE) has been prioritised for risk assessment under the EU "Existing S...
JACC

JACC Report 43 – sec-Butanol

JACC 043 : sec-Butanol (CAS No. 78-92-2) | March 2004 This report has been produced as part of the Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical evaluation of the...
JACC

JACC Report 42 – Tetrafluoroethylene

JACC 042 : Tetrafluoroethylene (CAS No. 116-14-3) | December 2003 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critica...
JACC

JACC Report 41 – n-Butanol

JACC 041 : n-Butanol (CAS No. 71-36-3) | March 2004 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical evaluation o...
Technical Report

TR 091 – ECETOC Aquatic Toxicity (EAT) database – EAT Database

TR 091 : ECETOC Aquatic Toxicity (EAT) database - EAT Database | November 2003 ECETOC Aquatic Toxicity (EAT) database ECETOC Aquatic Toxicity (EAT) database which was distributed on a cd with TR 091...
Technical Report

TR 091 – Aquatic Hazard Assessment II

TR 091 : Aquatic Hazard Assessment II | November 2003 The ECETOC Aquatic Toxicity (EAT) database (ECETOC, 1993) has been updated, mainly from data published between 1992 and 2000, to include informat...
Technical Report

TR 090 – Persistence of Chemicals in the Environment

TR 090 : Persistence of Chemicals in the Environment | October 2003 This review considers the current definition of persistence of chemicals in the environment, the factors that influence their degra...
Article

Linear Alkylbenzene sulphonate and boron monitoring in four catchments in the UK contribution to GREAT-ER project # 11

A comprehensive monitoring programme was carried out in the Aire, Calder, Went and Rother catchments in the UK. A total of 804 effluent samples from 36 sewage treatment works (STWs) and 1100 water sam...
Annual Report
Technical Report

TR 089 – (Q)SARs: Evaluation of the commercially available software for human health and environmental endpoints with respect to chemical management applications

TR 089 : (Q)SARs: Evaluation of the commercially available software for human health and environmental endpoints with respect to chemical management applications | September 2003 With the marked esca...
Article

Human inhalation exposure to ethylene glycol

Two male volunteers (A and B) inhaled 1.43 and 1.34 mmol, respectively, of vaporous 13C-labeled ethylene glycol (13C2-EG) over 4 h. In plasma, 13C2-EG and its metabolite 13C2-glycolic acid (13C2-GA)...
Document

DOC 043 – Contact Sensitisation: Classification According to Potency A commentary

DOC 043 : Contact Sensitisation: Classification According to Potency: A Commentary | July 2003 The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has recently published a re...
Technical Report

TR 088 – Environmental Risk Assessment of Difficult Substances

TR 088 : Environmental Risk Assessment of Difficult Substances | June 2003 Experience gained from the EU environmental risk assessments has shown that certain substances have properties that complica...
Technical Report

TR 087 – Contact Sensitisation: Classification According to Potency

TR 087 : Contact Sensitisation: Classification According to Potency | April 2003 Contact allergens vary substantially with regard to the relative potency with which they are able to induce skin sensi...
Technical Report

TR 086 – Derivation of Assessment Factors for Human Health Risk Assessment

TR 086 : Derivation of Assessment Factors for Human Health Risk Assessment | February 2003 In general, the risks to human health posed by chemical substances are assessed by the extrapolation of hete...
Monograph

Monograph 033 – Application of Physiological – Toxicokinetic Modelling to Health Hazard Assessment of Chemical Substances

Mono 033 : Application of Physiological - Toxicokinetic Modelling to Health Hazard Assessment of Chemical Substances | 18 February 2003...
Technical Report

TR 085 – Recognition of, and Differentiation between, Adverse and Non-adverse Effects in Toxicology Studies

TR 085 : Recognition of, and Differentiation between, Adverse and Non-adverse Effects in Toxicology Studies | December 2002 This report proposes a structured approach to assist the toxicologist in ar...
Technical Report

TR 084 – Scientific Principles for Soil Hazard Assessment of Substances

TR 084 : Scientific Principles for Soil Hazard Assessment of Substances | July 2002 This report reviews the scientific principles that should underpin any future terrestrial (soil) hazard classificat...
Technical Report

TR 083 – The Use of T25 Estimates and Alternative Methods in the Regulatory Risk Assessment of Non-threshold Carcinogens in the European Union

TR 083 : The Use of T25 Estimates and Alternative Methods in the Regulatory Risk Assessment of Non-threshold Carcinogens in the European Union | December 2002 The regulation of carcinogens in the Eur...
Annual Report
Monograph

Monograph 032 – Use of Human Data in Hazard Classification for Irritation and Sensitisation

Mono 032 : Use of Human Data in Hazard Classification for Irritation and Sensitisation | July 2002 Reference to the use of human data is made throughout the European legislation relating to the cla...
Monograph

Monograph 031 – Guidance on Evaluation of Reproductive Toxicity Data

Mono 031 : Guidance on Evaluation of Reproductive Toxicity Data | February 2002 The reproductive process is complex and there are many stages that are vulnerable to external influences; such influe...

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