2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Article

Respiratory Allergy: Hazard identification and risk assessment

Respiratory Allergy: Hazard Identification and Risk Assessment. Briatico-Vangosa, G., Braun, C. L. J., Cookman, G., Hofmann, T., Kimber, I., Loveless, S. E., Morrow, T., Pauluhn, J., Sorensen, T., and...
JACC

JACC Report 25 – 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC 124)

JACC 025 : 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC 124) (CAS No.2837-89-0) (Updated by JACC No. 46!) | July 1994...
Technical Report

TR 060 – Trichloroethylene: Assessment of Human Carcinogenic Hazard

TR 060 : Trichloroethylene: Assessment of Human Carcinogenic Hazard | May 1994 Trichloroethylene (TCE) has been manufactured on an industrial scale since the beginning of this century and it is used...
Technical Report

TR 058 – Assessment of Non-Occupational Exposure to Chemicals

TR 058 : Assessment of Non-Occupational Exposure to Chemicals | May 1994 The main objective of the work described in this report is to review the assumptions and equations used to assess non-occupati...
Technical Report

TR 059 – Testing for Worker Protection

TR 059 : Testing for Worker Protection | April 1994 A practical approach to risk assessment for occupational exposure standard setting and practical guidance on requirements for animal and human data...
JACC

JACC Report 24 – Pentafluoroethane (HFC 125)

JACC 024 : Pentafluoroethane (HFC 125) CAS No. 354-33-6 | May 1994...
Special Report

Special Report 07 – Butoxyethanol Criteria Document Including Supplement for 2-Butoxyethyl Acetate

SR 07 : Butoxyethanol Criteria Document (incl a supplement for 2-Butoxyethyl Acetate | April 1994...
Technical Report

TR 057 – Polypropylene Production and Colorectal Cancer

TR 057 : Polypropylene Production and Colorectal Cancer | February 1994 Polypropylene has been produced for over 35 years. It has a wide variety of applications including industrial, food packaging a...
Technical Report

TR 056 – Aquatic Toxicity Data Evaluation

TR 056 : Aquatic Toxicity Data Evaluation | December 1993 A database, termed the ECETOC Aquatic Toxicity (EAT) database, consisting of original published information on the toxicity of substances to...
Special Report

Special Report 06 – Interpretation – Evaluation of the Neurotoxic Potential of Chemicals in Animals

SR 06 : Interpretation - Evaluation of the Neurotoxic Potential of Chemicals in Animals | December 1993...
Special Report

Special Report 05 – Enviromental Health Criteria for Methylene Chloride

SR 05 : Environmental Health Criteria for Methylene Chloride | December 1996...
JACC

JACC Report 23 – Polycarboxylate Polymers as Used in Detergents

JACC 023 : Polycarboxylate Polymers as Used in Detergents | November 1993...
Technical Report

TR 055 – Pulmonary Toxicity of Polyalkylene Glycols

TR 055 : Pulmonary Toxicity of Polyalkylene Glycols | December 1997 Polyalkylene glycols (polyglycols; PAG) are a group of polymeric chemicals with a wide range of physicochemical properties and appl...
Technical Report

TR 054 – Assessment of the Biodegradation of Chemicals in the Marine Environment

TR 054 : Assessment of the Biodegradation of Chemicals in the Marine Environment | August 1993 Several test methods assessing the biodegradation potential of a chemical has been developed and validat...
Monograph

Monograph 020 – Percutaneous Absorption

Mono 020 : Percutaneous Absorption | August 1993...
Monograph

Monograph 019 – Respiratory Allergy

Mono 019 : Respiratory Allergy | August 1993  ...
Document

DOC 031 – Strategy for assigning a “Skin Notation”

DOC 031 : Strategy for assigning a skin notation | August 1993 In providing standards for occupational exposure, it has been recognised for a long time that inhalation is not the only route by whic...
Technical Report

TR 053 – DHTDMAC: Aquatic and Terrestrial Hazard Assessment (CAS No. 61789-80-8)

TR 053 : DHTDMAC: Aquatic and Terrestrial Hazard Assessment (CAS No. 61789-80-8) | February 1993 Dihydrogenatedtallow dimethyl ammonium chloride (DHTDMAC) is almost exclusively used as a fabric softe...
Technical Report

TR 052 – Styrene Toxicology Investigations on the Potential for Carcinogenicity

TR 052 : Styrene Toxicology Investigations on the Potential for Carcinogenicity | August 1992 At present there is no clear evidence that styrene is carcinogenic in laboratory animals or in man. The a...
Technical Report

TR 051 – Environmental Hazard Assessment of Substances

TR 051 : Environmental Hazard Assessment of Substances | January 1993 The main objective of the work described in this report was the development of a process for the Environmental Hazard Assessment...
Special Report

Special Report 04 – 1,3-Butadiene Criteria Document

SR 04 : 1,3-Butadiene Criteria Document | January 1993...
JACC

JACC Report 22 – Hydrogen Peroxide

JACC 022 : Hydrogen Peroxide (CAS:7722-84-1) | January 1993...
JACC

JACC Report 21 – Tris-(2-butoxyethyl)-phosphate

JACC 021 : Tris-(2-Butoxyethyl)-Phosphate (CAS:78-51-3) | March 1992...
Article

Nickel cobalt and chromium in consumer products: A role in allergic contact dermatitis?

In spite of the improved awareness of the potential for nickel, cobalt and chromium to en use skin allergy, the incidence of serialization to them is generally on the increase, especially for nickel....

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