2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

JACC

JACC Report 17 – Chlorodifluoroethane (1-chloro-1,1,difluoroethane; HFA 142b)

JACC 017 : Chlorodifluoroethane (1-chloro-1,1, difluoroethane; HFA 142 b) CAS: 75-68-3 | August 1990...
Technical Report

TR 041 – Human Exposure to N-Nitrosamines, Their Effects and a Risk Assessment for N-Nitrosodiethanolamine in Personal Care Products

TR 041 : Human Exposure to N-Nitrosamines, Their Effects and a Risk Assessment for N-Nitrosodiethanolamine in Personal Care Products | August 1990...
JACC

JACC Report 16 – Dichlorofluoromethane (HCFC-21)

JACC 016 : Dichlorofluoromethane (HCFC-21) CAS: 75-43-4 | August 1990...
JACC

JACC Report 15 – 1-Fluoro 1, e-Dichloroethane HFA-141B

JACC 015 : 1-Fluoro 1,1-Dichloroethane (HFA-141B) (Updated by JACC No. 29!) | August 1990...
JACC

JACC Report 14 – 1-Chloro-2,2,2-Trifluoroethane (HFA-133a)

JACC 014 : 1-Chloro-2,2,2-Trifluoroethane (HFA-133a) CAS: 75-88-7 | August 1990  ...
Technical Report

TR 039 – Hazard Assessment of Floating Chemicals After an Accidental Spill at Sea

TR 039 : Hazard Assessment of Floating Chemicals After an Accidental Spill at Sea | July 1990...
Technical Report

TR 038 – A Guide to the Classification of Preparations Containing Carcinogens, Mutagens and Teratogens

TR 038 : A Guide to the Classification of Preparations Containing Carcinogens, Mutagens and Teratogens | July 1990...
Monograph

Monograph 015 – Skin Irritation

Mono 015 : Skin Irritation | July 1990...
Technical Report

TR 037 – Tetrachloroethylene: Assessment of Human Carcinogenic Hazard

TR 037 : Tetrachloroethylene: Assessment of Human Carcinogenic Hazard | May 1990...
JACC

JACC Report 13 – 1,1-Dichloro-2,2,2-Trifluoroethane (HFA-123)

JACC 013 : 1,1-Dichloro-2,2,2-Trifluoroethane (HFA-123) (Updated by JACC No. 33) | May 1990...
JACC

JACC Report 12 – 1-Chloro-1,2,2,2-Tetrafluoroethane-(HFA-124)

JACC 012 : 1-Chloro-1,2,2,2-Tetrafluoroethane (HFA-124) (Updated by JACC No. 25!) | May 1990...
JACC

JACC Report 11 – 1,2-Dichloro-1, 1-Difluoroethane (HFA-132b)

JACC 011 : 1,2-Dichloro-1,1-Difluoroethane (HFA-132b) CAS: 1649-08-7 | May 1990...
Technical Report

TR 036 – Biomonitoring of Industrial Effluents

TR 036 : Biomonitoring of Industrial Effluents | April 1990...
Monograph

Monograph 014 – Skin Sensitisation Testing

Mono 014 : Skin Sensitisation Testing | March 1990...
Technical Report

TR 035 – Fate, Behaviour and Toxicity of Organic Chemicals Associated with Sediments

TR 035 : Fate, Behaviour and Toxicity of Organic Chemicals Associated with Sediments | January 1990...
Monograph

Monograph 012 – Alternative Approaches for the Assessment of Reproductive Toxicity (with emphasis on embryotoxicity/teratogenicity)

Mono 012 : Alternative Approaches for the Assessment of Reproductive Toxicity (with emphasis on embryotoxicity/teratogenicity) | November 1989...
JACC

JACC Report 10 – Isophrone

JACC 010 : Isophorone | September 1989...
Monograph

Monograph 013 – DNA and Protein Adducts: Evaluation of their Use in Exposure Monitoring and Risk Assessment

Mono 013 : DNA and Protein Adducts: Evaluation of their Use in Exposure Monitoring and Risk Assessment | October 1989...
JACC

JACC Report 09 – Chlorodifluoromethane

JACC 009 : Chlorodifluoromethane CAS: 75-45-6 | October 1989...
Article

Eye irritation: An ECETOC overview

The European Chemical Industry Ecology and Toxicology Center (ECETOC) has reviewed the Draize test and ways to evaluate the eye irritancy of chemicals with less reliance on animals. When animal test r...
Technical Report

TR 034 – Methylene Chloride (Dichloromethane): An Overview of Experimental Work Investigating Species Differences in Carcinogenicity and their Relevance to Man

TR 034 : Methylene Chloride (Dichloromethane): An Overview of Experimental Work Investigating Species Differences in Carcinogenicity and their Relevance to Man | March 1989...
Technical Report

TR 033 – Nickel and Nickel Compounds: Review of Toxicology and Epidemiology with Special Reference to Carcinogenesis

TR 033 : Nickel and Nickel Compounds: Review of Toxicology and Epidemiology with Special Reference to Carcinogenesis | February 1989...
Technical Report

TR 032 – Methylene Chloride (Dichloromethane): Human Risk Assessment Using Experimental Animal Data

TR 032 : Methylene Chloride (Dichloromethane): Human Risk Assessment Using Experimental Animal Data | May 1988...

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