Task Force
24.02.2026
Chronic fish case studies towards an IATA
Why?
- Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation.
- An Integrated Approach to Testing and Assessment (IATA) for chronic fish toxicity does not currently exist.
Objectives
- ECETOC Advisory Panel to work in liaison with contracted consultant to develop case studies, leveraging NAMs, to help shape future chronic fish toxicity IATA.
Timeline and Deliverables
- Timeline: end Q3 2025 - Q3 2027.
- Deliverables: Peer-reviewed manuscript(s) on case study findings, including proposed actions towards IATA.
Areas of work
NGRA and NAMsRecent Activities & Publications
- ‘Rethinking Chronic Fish Toxicity Testing: Case Studies Toward an Integrated Approach to Testing and Assessment’ – Poster at SETAC Maastricht 2026
- ‘ECETOC Chronic Fish Toxicity Case Studies’ – Presentation at EPAA NAM User Forum 2026 (ECHA, Helsinki, 7- 9 July)
- ‘3Rs for chronic fish toxicity – a stakeholder view’ – Presentation at SETAC Maastricht 2026 in Special Session on the implementation of the Commission Roadmap

