2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why? Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
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Publications

JACC

JACC Report 48A – Corrigenda to JACC No. 48

JACC 048a : Corrigendum to JACC 48 | December 2005 Corrigendum to JACC No. 48 - Hexafluoropropylene (CAS No. 116-15-4) Following publication of the above report, an erroneous reference to the EC...
JACC

JACC Report 48 – Hexafluoropropylene

JACC 048 : Hexafluoropropylene (CAS No. 116-15-4) | October 2005 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical...
Monograph

Monograph 034 – Toxicogenomics in Genetic Toxicology and Hazard Determination

Mono 034 : Toxicogenomics in Genetic Toxicology and Hazard Determination | 4 August 2005...
Technical Report

TR 096 – Trends in Children’s Health and the Role of Chemicals

TR 096 : Trends in Children's Health and the Role of Chemicals | July 2005 Children, compared to adults, can be more sensitive, less sensitive, or equally sensitive to changes in health status as a c...
JACC

JACC Report 47 – 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) Third edition

JACC 047 : 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123)CAS No. 306-83-2 (Third Edition) | July 2005 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC)...
Technical Report

TR 095 Vol II – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II – Substance Profiles

TR 095 Vol II : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II - Substance Profiles | March 2005 This report provides an update of an earlier ECETOC reviewa<...
Technical Report

TR 095 Vol I – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I

TR 095 Vol I : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I | March 2005 This report provides an update of an earlier ECETOC reviewa of a number of im...
Workshop Report

Workshop Report 05 – Alternative Testing Approaches in Environmental Risk Assessment

WR 05 : Alternative Testing Approaches in Environmental Risk Assessment | February 2005 This 2-day workshop, sponsored and organised by ECETOC, co-sponsored by ECVAM and Cefic LRI, took place at Cr...
Technical Report

TR 094 – Whole Effluent Assessment

TR 094 : Whole Effluent Assessment | February 2005 There is increasing recognition by regulators that there are limitations to the substance-specific approach for assessing and controlling the enviro...
Article

Mode of action and aquatic exposure thresholds of no concern

Threshold concepts of toxicological concern are based on the possibility of establishing an exposure threshold value for chemicals below which no significant risk is to be expected. The objective of t...
Technical Report

TR 093 – Targeted Risk Assessment

TR 093 : Targeted Risk Assessment | January 2005 One of the key challenges of the proposed European chemicals legislation (REACH) is that it envisages the registration and evaluation of approximately...
Technical Report

TR 092 – Soil and Sediment Risk Assessment of Organic Chemicals

TR 092 : Soil and Sediment Risk Assessment of Organic Chemicals | January 2005 In an assessment of the risks of chemicals to organisms in both the soil and sediment compartments, the estimation of th...
Workshop Report

Workshop Report 04 – Influence of Maternal Toxicity in Studies on Developmental Toxicity

WR 04 : Influence of Maternal Toxicity in Studies on Developmental Toxicity | October 2004 The Workshop was convened to explore whether the criteria to assess the influence of toxic effects induced...
Workshop Report

Workshop Report 03 – Workshop on the Use of Human Data in Risk Assessment

WR 03 : Workshop on the Use of Human Data in Risk Assessment | November 2004 Available human data are not always consistently addressed in chemical risk assessment, while questions of data quality...
JACC

JACC Report 46 – 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC 124) Second edition

JACC 046 : 1-Chloro-1,2,2,2-tetrafluoroethane (HCFC 124) CAS No. 2837-89-0 (Second Edition) | November 2004 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemica...
Annual Report
JACC

JACC Report 45 – 1,1-Difluoroethane (HFC-152a)

JACC 045 : 1,1-difluoroethane (HFC-152a) (CAS No. 75-37-6) | October 2004 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a...
JACC

JACC Report 44 – 1,1,1,3,3-Pentafluoropropane (HFC-245fa)

JACC 044 : 1,1,1,3,3-pentafluoropropane (HFC-245fa) (CAS No. 460-73-1) | June 2004 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It p...
Workshop Report

Workshop Report 02 – EQS and WFD versus PNEC and REACH – are they doing the job ?

WR 02 : EQS and WFD versus PNEC and REACH - are they doing the job ? | March 2004 This report arises out of a workshop that focussed on the concept of ecological quality status in terms of its defi...

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