2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

JACC

JACC Report 53 – Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin vol.I

JACC 053 Vol I : Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin (CAS No. 74-90-8, 143-33-9, 151-50-8 and 75-86-5), Volumes I and II | November 2007 This report has been produce...
Monograph

Monograph 037 – Biomarkers in Children and Adults

Mono 037 : Biomarkers in Children and Adults | 30 July 2007...
Article

Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop

The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop in Barcelona, Spain, in November 2005 to develop testing strategies to establish the safety of nanomateri...
Article

The ECETOC approach to targeted risk assessment, lessons and experiences relevant to REACH

ECETOC has been developed an approach by which the health and environmental risks arising from the supply and use of chemicals can be quickly and reliably evaluated by chemical suppliers. The approach...
Technical Report

TR 101 – Guidance for setting occupational exposure limits: Emphasis on data-poor substances

TR 101 : Guidance for setting occupational exposure limits: Emphasis on data-poor substances | October 2006 In the absence of sound human exposure data, existing procedures for setting occupational e...
Workshop Report

Workshop Report 08 – Workshop on societal aspects of nanotechnology

WR 08 : Workshop on societal aspects of nanotechnology | October 2006 Increasingly, public perception and acceptance are key factors in the introduction and development of new technologies. The quest...
JACC

JACC Report 52 – Trifluoroethane (HFC-143a)

JACC 052 : Trifluoroethane | October 2006 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical evaluation of the avai...
Annual Report
Workshop Report

Workshop Report 07 – Workshop on Testing Strategies to Establish the Safety of Nanomaterials

WR 07 : Workshop on Testing Strategies to Establish the Safety of Nanomaterials | September 2006 Nanotechnology produces an increasing number of engineered nanoparticles. A better understanding of...
Monograph

Monograph 036 – Environmental Genotoxins in Children and Adults

Mono 036 : Environmental Genotoxins in Children and Adults | 28 September 2006...
JACC

JACC Report 51 – Synthetic Amorphous Silica

JACC 051 : Synthetic Amorphous Silica | September 2006 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical evaluatio...
Monograph

Monograph 035 – Biomarkers and Molecular Epidemiology

Mono 035 : Biomarkers and Molecular Epidemiology | 31 August 2006...
Article

The potential risks of nanomaterials: a review carried out for ECETOC

During the last few years, research on toxicologically relevant properties of engineered nanoparticles has increased tremendously. A number of international research projects and additional activities...
Technical Report

TR 100 – Contribution to the Methodology for the Development of Acute Exposure Threshold Levels in Case of Accidental Chemical Release

TR 100 : Contribution to the Methodology for the Development of Acute Exposure Threshold Levels in Case of Accidental Chemical Release | July 2006 The ACUTEX project was a three-year research activit...
Technical Report

TR 099 – Toxicological Modes of Action: Relevance for Human Risk Assessment

TR 099 : Toxicological Modes of Action: Relevance for Human Risk Assessment | July 2006 Generally, the assessment of hazard and risk to humans that might arise from exposure to chemical substances is...
Workshop Report

Workshop Report 06 – Workshop on Chemical Pollution, Respiratory Allergy and Asthma

WR 06 : Workshop on Chemical Pollution, Respiratory Allergy and Asthma | February 2006 Atopic allergy and asthma remain important health issues. It is therefore of significance that in more moderni...
Technical Report

TR 098 – Risk Assessment of PBT Chemicals

TR 098 : Risk Assessment of PBT Chemicals | December 2005 Many chemical regulatory schemes exist around the world that contain hazard-based criteria to identify and prioritise persistent, bioaccumula...
Technical Report

TR 097 – Alternative Testing Approaches in Environmental Safety Assessment

TR 097 : Alternative Testing Approaches in Environmental Safety Assessment | January 2006 There are many opportunities for applying the principles of the three Rs (replacement, reduction and refineme...
JACC

JACC Report 50 – 1,1,1,2-Tetrafluoroethane (HFC-134a) Second edition

JACC 050 : 1,1,1,2-Tetrafluoroethane (HFC-134a) (CAS No. 811-97-2) (Second Edition) | January 2006 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC)...
JACC

JACC 049a : Corrigendum to JACC 49

Following publication of the above mentioned report, some errors have been brought to our attention. Please note that the corrections of the printed and PDF versions of the JACC Report No. 49 are as f...
JACC

JACC Report 49 – Vinylidene Fluoride

JACC 049 : Vinylidene Fluoride (CAS No. 75-38-7) | November 2005 This report has been produced as part of the ECETOC Joint Assessment of Commodity Chemicals (JACC) programme. It presents a critical...
Document

DOC 044 – Guidance for the Interpretation of Biomonitoring Data

DOC 044 : Guidance for the Interpretation of Biomonitoring Data | November 2005 Measuring the levels of chemical substances in human body fluids and tissues has been in routine use in industry and...
Annual Report

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