2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme! ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

TR 123 – Environmental risk assessment of ionisable compounds
Technical Report

TR 123 – Environmental risk assessment of ionisable compounds

SCIENCE NEWS FLASH: New ECETOC report addresses environmental exposure assessment of ionisable organic compounds When predicting the concentration of an ionisable chemical in the environment (a...
TR 122 – Poorly Soluble Particles / Lung Overload
Technical Report

TR 122 – Poorly Soluble Particles / Lung Overload

SCIENCE NEWS FLASH: New ECETOC report addresses poorly soluble particles and lung overload   Brussels, January 2014 Despite being regarded as biologically inert, many poorly soluble substan...
Technical Report

TR 121 – Efficacy and safety of antidotes for acute poisoning by cyanides

TR 121 : Efficacy and safety of antidotes for acute poisoning by cyanides | 19 November 2013 SCIENCE NEWS FLASH: New ECETOC report offers guidance on the efficacy and safety of antidotes for acute p...
TR 120 – Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions
Technical Report

TR 120 – Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions

TR 120 : Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions | 13 January 2014 Technical Report no.120. Activity-Based Relationsh...
Article

Risk assessment of endocrine disrupting chemicals – Introduction to this special issue

Highlights The editors of this special issue introduce the 8 papers on risk assessment of endocrine disrupting chemicals, for both human health and the environment. Endocrine disruption is a m...
Article

Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS) 29 November 2013

The Globally Harmonised System of Classification (GHS) is a framework within which the intrinsic hazards of substances may be determined and communicated. It is not a legislative instrument per se, bu...
Article

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

Highlights Alternatives are yet only available for acute fish toxicity testing. Limited access to animal test data hinders the development of alternatives. Successful validation of alternative...
Workshop Report 27 – Expert Panel to Better Understand Endocrine Disrupter Low Doses Effects
Workshop Report

Workshop Report 27 – Expert Panel to Better Understand Endocrine Disrupter Low Doses Effects

SUMMARY 1. This expert panel was convened by ECETOC to discuss the issue of so-called low dose effects of endocrine disrupting chemicals (EDC), and to propose a possible research programme to throw...
Workshop Report

Workshop Report 26 – Mode of Action: Recent Developments, Regulatory Application and Future Work

WR 26 : Mode of Action: Recent Developments, Regulatory Application and Future Work | 27 June 2013 Workshop Report no.26. Mode of Action: Recent Developments, Regulatory Applications and Future Work...
Workshop Report

Workshop Report 25 – Workshop on ‘Omics and Risk Assessment Science

WR 25 : Workshop on 'Omics and Risk Assessment Science | 3 October 2013 Workshop Report no.25. 'Omics and risk assessment science 25-26 February 2013, Málaga ISSN-2078-7200-25 (print) ISSN-2078-72...
Workshop Report

Workshop Report 24 – Assessing Environmental Persistence

WR 24 : Assessing Environmental Persistence | 17 December 2013 ECETOC WR24. Assessing Environmental Persistence, 6-7 November 2012, Paris   ISSN-2078-7200-24 (print) ISSN-2078-7219-24 (onli...
A systematic approach for evaluating and scoring human data
Article

A systematic approach for evaluating and scoring human data

An approach is described for how the quality of human data can be systematically assessed and categorised. The approach mirrors the animal data quality considerations set out by Klimisch et al., in or...
Article

Use of category approaches, read-across and (Q)SAR: General considerations

Read-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU?s REACH regulation. Rea...
Technical Report

TR 119 – Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals

TR 119 : Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals | 26 March 2013 Technical Report no.119. Evaluation of systemic health effects following dermal exposure to che...

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