2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation. Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Workshop Report 28 – Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions
Workshop Report

Workshop Report 28 – Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions

WR 28 : Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions | 02/12/2014 IN A NUTSHELL Predicting the toxicity of chemicals to aquatic communities is an...
Article

Incorporating potency into EU classification for carcinogenicity and reproductive toxicity

Although risk assessment, assessing the potential harm of each particular exposure of a substance, is desirable, it is not feasible in many situations. Risk assessment uses a process of hazard identif...
Special Report 18 – Information to be considered in a weight-of-evidence-based PBT/vPvB assessment of chemicals (Annex XIII of REACH)
Special Report

Special Report 18 – Information to be considered in a weight-of-evidence-based PBT/vPvB assessment of chemicals (Annex XIII of REACH)

SCIENCE NEWS FLASH: ECETOC publishes report on new information and weight-of-evidence in PBT/vPvB assessment of chemicals Brussels, 1st August 2014 An ECETOC task force has reviewed th...
ArticleTechnical ReportWorkshop Report

ED Pack – ECETOC publications on endocrine disrupting chemicals (updated 10 July 2014)

Publisher : This is the updated version of the package of ECETOC publications relating to endocrine disrupting chemicals originally published in October 2012. It comprises: Report commissione...
TR 124 – Addendum to TR114 : Technical Basis for the TRA v3.1
Technical Report

TR 124 – Addendum to TR114 : Technical Basis for the TRA v3.1

TR124: Addendum to TR114 : Technical Basis for the TRA v3.1 Newsflash: In response to feedback received from users of the TRA, ECETOC has further improved the consumer portion of the model by the in...
Technical Report

Environmental Exposure Assessment of Ionisable Organic Compounds

When predicting the concentration of an ionisable chemical in the environment (an important step in risk assessment), it should be realised that the compound may have different key properties (acidity...
Technical Report

Poorly Soluble Particles / Lung Overload

Brussels, January 2014 Despite being regarded as biologically inert, many poorly soluble substances can still cause toxicity when high concentrations of small particles are inhaled repeatedly over...
Technical Report

Efficacy and safety of antidotes for acute poisoning by cyanides Volume I

Brussels, November 2013 When it happens, cyanide poisoning can have very serious neurological consequences that may result in severe disability and death. Cyanide poisoning may occur after swallowi...
Evaluation of systemic health effects following dermal exposure to chemicals
Technical Report

Evaluation of systemic health effects following dermal exposure to chemicals

Technical Report no.119. Evaluation of systemic health effects following dermal exposure to chemicals ISSN-0773-8072-119 (print) ISSN-2079-1526-119 (online) D-2013-3001-227 Science Newsflash...
Mode of Action: Recent developments, regulatory application and future work

Mode of Action: Recent developments, regulatory application and future work

Workshop Report no.26. Mode of Action: Recent Developments, Regulatory Applications and Future Work 21-22 February 2013, Vienna ISSN-2078-7200-26 (print) ISSN-2078-7219-26 (online) D-2013-3001-228 SCI...
Endocrine Disrupting Chemicals: Package of ECETOC publications on ED

Endocrine Disrupting Chemicals: Package of ECETOC publications on ED

This is the updated version of the package of ECETOC publications relating to endocrine disrupting chemicals originally published in October 2012. It comprises: Report commissioned by ECETOC Expone...
Understanding the relationship between extraction technique and bioavailability
Technical Report

Understanding the relationship between extraction technique and bioavailability

Technical Report no.117. Understanding the relationship between extraction technique and bioavailability ISSN-0773-8072-117 (print) ISSN-2079-1526-117 (online) D-2013-3001-225 Science Newsflas...
Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals
Technical Report

Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals

Technical Report no.118. Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals ISSN-0773-8072-118 (print) ISSN-2079-1526-118 (onl...
‘Omics and risk assessment science. 25-26 February 2013, Málaga
Technical Report

‘Omics and risk assessment science. 25-26 February 2013, Málaga

Workshop Report no.25. 'Omics and risk assessment science 25-26 February 2013, Málaga ISSN-2078-7200-25 (print) ISSN-2078-7219-25 (online) D-2013-3001-229 SCIENCE NEWS FLASH ECETOC report...
Expert Panel to better understand Endocrine Disrupter Low Doses Effects 22-23 April 2013, Barcelona
Technical Report

Expert Panel to better understand Endocrine Disrupter Low Doses Effects 22-23 April 2013, Barcelona

1. This expert panel was convened by ECETOC to discuss the issue of so-called low dose effects of endocrine disrupting chemicals (EDC), and to propose a possible research programme to throw more light...
Assessing Environmental Persistence, 6-7 November 2012, Paris
Technical Report

Assessing Environmental Persistence, 6-7 November 2012, Paris

ECETOC WR24. Assessing Environmental Persistence, 6-7 November 2012, Paris ISSN-2078-7200-24 (print) ISSN-2078-7219-24 (online) D-2013-3001-231 SCIENCE NEWS FLASHECETOC reports on November 201...
Activity-Based Relationships for Aquatic Ecotoxicology Data:  Use of the Activity Approach to Strengthen MoA Predictions
Technical Report

Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions

Technical Report no.120. Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions ISSN-0773-8072-120 (print) ISSN-2079-1526-120 (on...
ECETOC 2013 Annual Report
Annual Report

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