2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme! ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
a

Publications

ECETOC 2012 Annual Report
Annual Report
Technical Report

TR 118 – Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals

TR 118 : Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals | 29 May 2013 Technical Report no.118. Development of interim guid...
Technical Report

TR 117 – Understanding the relationship between extraction technique and bioavailability

TR 117 : Understanding the relationship between extraction technique and bioavailability | 27 May 2013 Technical Report no.117. Understanding the relationship between extraction technique and bioav...
Article

Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology

To use and implement an assessment scheme for the evaluation of endocrine disrupting properties of chemicals in ecotoxicology, the types of effect need to be agreed. Effects that merit further conside...
Technical Report

TR 116 – Category approaches, read-across, (Q)SAR

TR 116 : Category approaches, read-across, (Q)SAR | 21 November 2012 Background An accepted practice for the assessment of human health and environmental safety of chemicals is the use of models...
Article

Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern

The European regulation on plant protection products (1107/2009) (EC, 2009a), the revisions to the biocides Directive (COM267) (EC, 2009b), and the regulation concerning chemicals (Regulation (EC) No....
Article

Use of ‘Omics to Elucidate Mechanism of Action and Integration of ‘Omics in a Systems Biology Concept.

This special issue of Mutation Research may demonstrate to the reader that 'omics technologies are beginning to take their place among other routinely used approaches for chemical hazard/risk assessme...
Technical Report

TR 114 – ECETOC TRA version 3: Background and Rationale for the Improvements

TR 114 : ECETOC TRA version 3: Background and Rationale for the Improvements | 30 July 2012 SUMMARY The ECETOC Targeted Risk Assessment (TRA) tool was launched in 2004. The TRA consists of 3 separat...
Workshop Report

Workshop Report 23 – ECETOC Workshop Report 23 – Epigenetics and Chemical Safety

WR 23 : ECETOC WR 23 - Epigenetics and Chemical Safety | 18 June 2012 Epigenetics is a rapidly developing and expanding biological science which will change our perception of cell biology in a prof...
2011 Annual Report
Annual Report
Article

2012 Art. – Workshop: Combined exposure to chemicals.

Authors : Hennes EC, Galay Burgos M, Hamer M, Pemberton M, Travis K, Rodriguez C Publisher : Regulatory Toxicology and Pharmacology 63:53-54. doi: 10.1016/j.yrtph.2012.02.008...
JACC

JACC Report 55 – Linear Polydimethylsiloxanes second edition

JACC 055 : Linear Polydimethylsiloxanes CAS No. 63148-62-9 (Second Edition) | December 2011 ISSN-0773-6339-55 print ISSN-2079-1496-55 online D-2011-3001-220 EXECUTIVE SUMMARY This report pr...
Workshop Report

Workshop Report 22 – Workshop on Combined Exposure to Chemicals

WR 22 : Workshop on Combined Exposure to Chemicals | October 2011 Workshop on Combined Exposure to Chemicals. 11-12 July 2011, Berlin Published October 2011 ISSN-2078-7200-22 (print) ISSN-2078...
Workshop Report

Workshop Report 21 – Risk Assessment of Endocrine Disrupting Chemicals

WR 21 : Risk Assessment of Endocrine Disrupting Chemicals | November 2011 WR 21 Risk Assessment of Endocrine Disrupting Chemicals 9-10 May 2011, Florence ISSN-2078-7200-21 (print) ISSN-2078-721...
Technical Report

TR 113 – Environmental Impact Assessment for Socio-Economic Analysis of Chemicals: Principles and Practice

TR 113 : Environmental Impact Assessment for Socio-Economic Analysis of Chemicals: Principles and Practice | August 2011 This report describes the requirements for, and illustrates the application...
Technical Report

TR 112 – Refined Approaches for Risk Assessment of PBT/vPvB Chemicals

TR 112 : Refined Approaches for Risk Assessment of PBT/vPvB Chemicals | October 2011 ISSN-0773-8072-112 (print) ISSN-2079-1526-112 (online) D-2011-3001-218 Summary Building upon a previous EC...
Technical Report

TR 111 – Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment

TR 111 : Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment | October 2011 ISSN-0773-8072-111 (print) ISSN-2079-1526-111 (online) D-2011-3001-215...
Article

Corrigendum: Science based guidance for the assessment of endocrine disrupting properties of chemicals.

The European legislation on plant protection products (Regulation (EC) No. 1107/2009) and biocides (Directive 98/8/EC), as well as the regulation concerning chemicals (Regulation (EC) No. 1907/2006 ?R...
Article

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), the International Life Sciences Institute (ILSI) Research Foundation (RF), and the ILSI Health and Environmental Sciences In...
2010 Annual Report
Annual Report

Don’t miss an event

Always stay in the loop by signing up to the ECETOC Newsletter