New ECETOC expert report: Advancing OECD TG 309 biodegradation testing
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New ECETOC expert report: Advancing OECD TG 309 biodegradation testing

A new expert meeting report is now available on the ECETOC website exploring how OECD TG 309 can be made more robust and environmentally relevant for chemical persistence assessment. The report ref...
We’re Hiring: Join the ECETOC Team as a Trainee!
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We’re Hiring: Join the ECETOC Team as a Trainee!

Are you passionate about science, regulatory toxicology, and making a real-world impact at the intersection of industry, academia, and policy? ECETOC is excited to announce that we’re looking for a...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why? Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
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Publications

Article

Use of category approaches, read-across and (Q)SAR: General considerations

Read-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU?s REACH regulation. Rea...
Technical Report

TR 119 – Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals

TR 119 : Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals | 26 March 2013 Technical Report no.119. Evaluation of systemic health effects following dermal exposure to che...
ECETOC 2012 Annual Report
Annual Report
Technical Report

TR 118 – Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals

TR 118 : Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals | 29 May 2013 Technical Report no.118. Development of interim guid...
Technical Report

TR 117 – Understanding the relationship between extraction technique and bioavailability

TR 117 : Understanding the relationship between extraction technique and bioavailability | 27 May 2013 Technical Report no.117. Understanding the relationship between extraction technique and bioav...
Article

Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology

To use and implement an assessment scheme for the evaluation of endocrine disrupting properties of chemicals in ecotoxicology, the types of effect need to be agreed. Effects that merit further conside...
Technical Report

TR 116 – Category approaches, read-across, (Q)SAR

TR 116 : Category approaches, read-across, (Q)SAR | 21 November 2012 Background An accepted practice for the assessment of human health and environmental safety of chemicals is the use of models...
Article

Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern

The European regulation on plant protection products (1107/2009) (EC, 2009a), the revisions to the biocides Directive (COM267) (EC, 2009b), and the regulation concerning chemicals (Regulation (EC) No....
Article

Use of ‘Omics to Elucidate Mechanism of Action and Integration of ‘Omics in a Systems Biology Concept.

This special issue of Mutation Research may demonstrate to the reader that 'omics technologies are beginning to take their place among other routinely used approaches for chemical hazard/risk assessme...
Technical Report

TR 114 – ECETOC TRA version 3: Background and Rationale for the Improvements

TR 114 : ECETOC TRA version 3: Background and Rationale for the Improvements | 30 July 2012 SUMMARY The ECETOC Targeted Risk Assessment (TRA) tool was launched in 2004. The TRA consists of 3 separat...
Workshop Report

Workshop Report 23 – ECETOC Workshop Report 23 – Epigenetics and Chemical Safety

WR 23 : ECETOC WR 23 - Epigenetics and Chemical Safety | 18 June 2012 Epigenetics is a rapidly developing and expanding biological science which will change our perception of cell biology in a prof...
2011 Annual Report
Annual Report
Article

2012 Art. – Workshop: Combined exposure to chemicals.

Authors : Hennes EC, Galay Burgos M, Hamer M, Pemberton M, Travis K, Rodriguez C Publisher : Regulatory Toxicology and Pharmacology 63:53-54. doi: 10.1016/j.yrtph.2012.02.008...
JACC

JACC Report 55 – Linear Polydimethylsiloxanes second edition

JACC 055 : Linear Polydimethylsiloxanes CAS No. 63148-62-9 (Second Edition) | December 2011 ISSN-0773-6339-55 print ISSN-2079-1496-55 online D-2011-3001-220 EXECUTIVE SUMMARY This report pr...
Workshop Report

Workshop Report 22 – Workshop on Combined Exposure to Chemicals

WR 22 : Workshop on Combined Exposure to Chemicals | October 2011 Workshop on Combined Exposure to Chemicals. 11-12 July 2011, Berlin Published October 2011 ISSN-2078-7200-22 (print) ISSN-2078...
Workshop Report

Workshop Report 21 – Risk Assessment of Endocrine Disrupting Chemicals

WR 21 : Risk Assessment of Endocrine Disrupting Chemicals | November 2011 WR 21 Risk Assessment of Endocrine Disrupting Chemicals 9-10 May 2011, Florence ISSN-2078-7200-21 (print) ISSN-2078-721...
Technical Report

TR 113 – Environmental Impact Assessment for Socio-Economic Analysis of Chemicals: Principles and Practice

TR 113 : Environmental Impact Assessment for Socio-Economic Analysis of Chemicals: Principles and Practice | August 2011 This report describes the requirements for, and illustrates the application...
Technical Report

TR 112 – Refined Approaches for Risk Assessment of PBT/vPvB Chemicals

TR 112 : Refined Approaches for Risk Assessment of PBT/vPvB Chemicals | October 2011 ISSN-0773-8072-112 (print) ISSN-2079-1526-112 (online) D-2011-3001-218 Summary Building upon a previous EC...
Technical Report

TR 111 – Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment

TR 111 : Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment | October 2011 ISSN-0773-8072-111 (print) ISSN-2079-1526-111 (online) D-2011-3001-215...
Article

Corrigendum: Science based guidance for the assessment of endocrine disrupting properties of chemicals.

The European legislation on plant protection products (Regulation (EC) No. 1107/2009) and biocides (Directive 98/8/EC), as well as the regulation concerning chemicals (Regulation (EC) No. 1907/2006 ?R...

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