New ECETOC expert report: Advancing OECD TG 309 biodegradation testing

A new expert meeting report is now available on the ECETOC website exploring how OECD TG 309 can be made more robust and environmentally relevant for chemical persistence assessment. The report ref...

09.09.2026 Read more

We’re Hiring: Join the ECETOC Team as a Trainee!

Are you passionate about science, regulatory toxicology, and making a real-world impact at the intersection of industry, academia, and policy? ECETOC is excited to announce that we’re looking for a...

25.08.2026 Read more

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).

03.10.2025 Read more

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure

03.10.2025 Read more

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.

03.10.2025 Read more

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.

03.10.2025 Read more

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...

04.08.2026 Read more

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task Limited regulatory guidance exists Lack of industry and regulatory knowledge...

30.07.2026 Read more

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....

24.02.2026 Read more

02.03.2012

An overview of values for the threshold of toxicological concern March 2012

Reference

Authors : Hennes EC
Publisher : Toxicology Letters 211(3):296?303 doi: 10.1016/j.toxlet.2012.03.795

Find out more

http://www.sciencedirect.com/science/article/pii/S0378427412008971

Expert Report: Advancing OECD TG 309 biodegradation testing

Framework for Risk Assessment of Plastic Additives

Repeat Dose Toxicity testing workshop: From concept to application

Planetary boundary for novel entities

New ECETOC expert report: Advancing OECD TG 309 biodegradation testing

We’re Hiring: Join the ECETOC Team as a Trainee!

HSSD Tool

The Human Exposure Assessment Tools Database (heatDB)

NanoApp

Targeted Risk Assessment (TRA)

TRA Task Force – Worker branch

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]

Chronic fish case studies towards an IATA

An overview of values for the threshold of toxicological concern March 2012