January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...

29.01.2026 Read more

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme!ECETOC is looking for early-career scientists currently working at a member co...

13.11.2025 Read more

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).

03.10.2025 Read more

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure

03.10.2025 Read more

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.

03.10.2025 Read more

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.

03.10.2025 Read more

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....

24.02.2026 Read more

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why?REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...

24.02.2026 Read more

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...

07.07.2025 Read more

02.08.2009

Thresholds for genotoxins and their application in risk assessment

Reference

Carmichael P, Kirsch-Volders M, eds. 2009.
Thresholds for genotoxins and their application in risk assessment.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 678(2):71 Doi:10.1016/j.mrgentox.2009.04.012

Find out more

http://dx.doi.org/10.1016/j.mrgentox.2009.04.012

2025 Annual Report

Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop

From concept to application: Repeat dose toxicity testing workshop

Planetary boundary for novel entities

January 2026 news from the Sec Gen

ECETOC launches Secondee Programme

HSSD Tool

The Human Exposure Assessment Tools Database (heatDB)

NanoApp

Targeted Risk Assessment (TRA)

Chronic fish case studies towards an IATA

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Thresholds for genotoxins and their application in risk assessment