Active task forces
ECETOC task forces are established by ECETOC’s Scientific Committee in response to an identified need or objective, which typically sit within the framework of its strategy.
The work of an ECETOC task force follows a terms of reference established by the Scientific Committee. Each task force is directed by a chair, who is responsible for assuring the completion of its objectives. And each task force is supported by a scientific officer from the ECETOC Secretariat.
25.05.2018
Assessing the human health and environmental safety of polymers
Terms of Reference
Considering existing risk assessment approaches (e.g. food safety regulation, EU Technical Guidance Document/REACH Guidance, international polymer assessment frameworks), devel...
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13.06.2019
Dose Selection Task Force
Terms of Reference
Provide guidance for dose-setting in repeated-dose toxicity studies. In the development of the guidance, the following elements will be included:
Critical review of th...
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04.04.2022
Inhalation Toxicological Properties of Low Soluble Particles and Their Relevance for C&L
Background
Poorly soluble particulate substances of low toxicity are progressively coming under intense regulatory pressure culminating in unjustified additional testing (see the extensive data pac...
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13.06.2019
Mid-tier approach to aggregated exposure assessment TF
Background
There are increasing public and regulatory concerns regarding potential health risks posed by aggregate exposure, i.e. exposure to (the same) substance from multiple sources via multiple r...
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29.04.2019
Moving persistence (P) assessments into the 21st Century: Developing a new paradigm to assess degradation potential of chemicals
Background
Recent progress in the scientific understanding of the underlying processes of persistence and degradation has provided an opportunity to develop an improved framework and best practices f...
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18.12.2018
Persistent chemicals and water resources protection
Background
Several initiatives end-2017 and 2018 on identification of substances of concern to drinking water resources.
ECETOC role in supporting the development of a science-based framework to a...
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17.02.2023
Smart studies: Examine how in vivo studies could provide more information encompassing novel studies (and endpoints)
Background:
Extended or “smart” studies can be defined as in vivo studies that employ additional or different endpoints from conventional studies.
They fall into 2 categories:
• those that...
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07.08.2018
Special T4 Task Force
Background
A potential connection between reduction of thyroid hormones, in particular thyroxine (T4), and impaired neuronal (mental) development in children is being discussed. This debate has cause...
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17.02.2023
Staged assessment: Exemplify the staged assessment process by using it to provide more information in low tonnage bands
Background:
The current paradigm for identifying data (study) requirements is based upon a surrogate of exposure, namely production volume. This approach offers the potential to provide a fuller asse...
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03.07.2023
Substances that activate various liver receptors as endocrine disruptors
Background
The current development of NAMs in the field of endocrine disruption (ED) is very active as the concept of ED is evolving in various areas of toxicology including liver toxicity/xenobiot...
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28.10.2015
Targeted Risk Assessment: TRA Tool Steering Team
Introduction
ECETOC initiated its targeted risk assessment (TRA) activity in 2001 and the first public version (v1) of the TRA exposure model was made available in 2004. Since then the TRA tool has c...
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04.04.2022
Use of clinical data in identification of respiratory sensitisers
Background
RAC has for the first time made a Classification and labelling (CLH) proposal to classify a chemical as a respiratory sensitiser based upon national surveillance data and the presence of...
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