HH TP staged assessment: Exemplify the staged assessment process by using it to provide more information in low tonnage bands

Background:

The current paradigm for identifying data (study) requirements is based upon a surrogate of exposure, namely production volume. This approach offers the potential to provide a fuller assessment of low tonnage chemicals by incorporating NAMs in a staged approach.

Objectives:

• Hazard identification/characterization with a defendable level of confidence, that could be applied to classification and risk assessment
• Provision fuller assessment of Tonnage bands: < 100 tpa and for assessment of impurities.
• Assessment of weight of evidence methodology
• Assessment of how the the current classification scheme can be modifies to accommodate the use of NAMs

Deliverable:

Peer reviewed paper for discussion with relevant stakeholders (e.g. regulators, industry/ EPAA, NC3Rs).