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A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Highlights ? Alternatives are yet only available for acute fish toxicity testing.? Limited access to animal test data hinders the development of alternatives.? Successful validation of alternative app...
Workshop Report 27 – Expert Panel to Better Understand Endocrine Disrupter Low Doses Effects
SUMMARY 1. This expert panel was convened by ECETOC to discuss the issue of so-called low dose effects of endocrine disrupting chemicals (EDC), and to propose a possible research programme to throw m...
Workshop Report 26 – Mode of Action: Recent Developments, Regulatory Application and Future Work
WR 26 : Mode of Action: Recent Developments, Regulatory Application and Future Work | 27 June 2013 Workshop Report no.26. Mode of Action: Recent Developments, Regulatory Applications and Future Work 2...
Workshop Report 25 – Workshop on ‘Omics and Risk Assessment Science
WR 25 : Workshop on 'Omics and Risk Assessment Science | 3 October 2013 Workshop Report no.25. 'Omics and risk assessment science 25-26 February 2013, Málaga ISSN-2078-7200-25 (print) ISSN-2078-7219-...
Workshop Report 24 – Assessing Environmental Persistence
WR 24 : Assessing Environmental Persistence | 17 December 2013 ECETOC WR24. Assessing Environmental Persistence, 6-7 November 2012, Paris ISSN-2078-7200-24 (print) ISSN-2078-7219-24 (online) D...
A systematic approach for evaluating and scoring human data
An approach is described for how the quality of human data can be systematically assessed and categorised. The approach mirrors the animal data quality considerations set out by Klimisch et al., in or...
Use of category approaches, read-across and (Q)SAR: General considerations
Read-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU?s REACH regulation. Rea...
TR 119 – Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals
TR 119 : Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals | 26 March 2013 Technical Report no.119. Evaluation of systemic health effects following dermal exposure to chemi...
TR 118 – Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals
TR 118 : Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals | 29 May 2013 Technical Report no.118. Development of interim guidanc...
TR 117 – Understanding the relationship between extraction technique and bioavailability
TR 117 : Understanding the relationship between extraction technique and bioavailability | 27 May 2013 Technical Report no.117. Understanding the relationship between extraction technique and bioavai...
Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology
To use and implement an assessment scheme for the evaluation of endocrine disrupting properties of chemicals in ecotoxicology, the types of effect need to be agreed. Effects that merit further conside...
TR 116 – Category approaches, read-across, (Q)SAR
TR 116 : Category approaches, read-across, (Q)SAR | 21 November 2012 Background An accepted practice for the assessment of human health and environmental safety of chemicals is the use of models and...
Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern
The European regulation on plant protection products (1107/2009) (EC, 2009a), the revisions to the biocides Directive (COM267) (EC, 2009b), and the regulation concerning chemicals (Regulation (EC) No....
Use of ‘Omics to Elucidate Mechanism of Action and Integration of ‘Omics in a Systems Biology Concept.
This special issue of Mutation Research may demonstrate to the reader that 'omics technologies are beginning to take their place among other routinely used approaches for chemical hazard/risk assessme...
TR 114 – ECETOC TRA version 3: Background and Rationale for the Improvements
TR 114 : ECETOC TRA version 3: Background and Rationale for the Improvements | 30 July 2012 SUMMARY The ECETOC Targeted Risk Assessment (TRA) tool was launched in 2004. The TRA consists of 3 separate...
Workshop Report 23 – ECETOC Workshop Report 23 – Epigenetics and Chemical Safety
WR 23 : ECETOC WR 23 - Epigenetics and Chemical Safety | 18 June 2012 Epigenetics is a rapidly developing and expanding biological science which will change our perception of cell biology in a profou...
