Workshop Report 30


3-MC                               3-methyl cholanthrene

5AC                                  5-azacytidine

5-mC                               5-methylcytosine

5hmC                             5-hydroxymethylcytosine


AhR                                  Aryl hydrocarbon receptor

AhRKO                           Aryl hydrocarbon receptor knock-out

AOP                                 Adverse outcome pathway

BPA                                  Bisphenol A

bw                                    Bodyweight


CoE CERAD                  Centre of Excellence for Environmental Radioactivity

CRO                                 Contract research organisation

DBP                                 Di-n-butyl phthalate (Dibutyl phthalate)

DEHP                              Diethylhexyl phthalate

DES                                  Diethylstilbestrol

DNA                                 Deoxyribonucleic acid


EDC                                  Endocrine disrupting chemical

EGF                                  Epidermal growth factor

EPA                                  (US) Environmental Protection Agency

ER                                     Oestrogen receptor

EU                                     European Union

EWAS                              Epigenome-wide association studies


F1                                      First generation of offspring

F2                                      Second generation of offspring

F3                                      Third generation of offspring

F4                                      Fourth generation of offspring

FET                                   Fish embryo toxicity

FGF                                  Fibroblast growth factor


GD                                    Gestation day

GLP                                  Good Laboratory Practice

IGF-1                               Insulin-like growth factor I

LC-MS                             Liquid chromatography - mass spectrometry

Lin                                    Linuron

MEHP                             Mono(2 ethylhexyl)phthalate

miRNA                           MicroRNA

MoA                                Mode of action

MOE                                Margin of exposure

MRC                                Medical Research Council

ncRNA                            Non-coding ribonucleic acid

NGC                                 Non-genotoxic carcinogen

NIHS                                National Institute of Health Sciences

NOAEL                            No observed adverse effect level

OECD                              Organisation for Economic Co-Operation and Development

P0                                      Parental generation

PBML                              Primary bone marrow lymphomas

nihsPPAR                     Peroxisome proliferator-activated receptor

PTMs                              Post-translational modifications


Q-PCR                             Quantitative polymerase chain reaction

QSAR                               Quantitative structure-activity relationship

RfP                                   Request for proposal

RNA                                 Ribonucleic acid

RRBS                               Reduced representation bisulphite sequencing

SD                                     Sex determination


TCDD                              2,3,7,8-tetrachlorinated dibenzo-p-dioxin / 2,3,7,8-tetrachlorodibenzo-p-dioxin

TDG                                 Thymine-DNA glycosylase

TG                                     Test Guideline

TGE                                  Transgenerational effects

WD                                  Wolffian duct