Workshop Report 30
- Pages
- EXECUTIVE SUMMARY
- AIM OF THE WORKSHOP
- PLENARY LECTURES
- Level Setting: Reproductive Toxicity Studies and Epigenetic Studies
- What are reproductive toxicity guideline studies? Why are they conducted? What can they achieve? Where are the gaps?
- What are epigenetic studies? Technical aspects and data interpretation to achieve confidence in epigenetic studies (human epidemiology and animal-based studies)
- Effects on rat reproductive development produced by antiandrogens: upstream indicators of downstream effects
- Effects on rat reproductive development produced by antiandrogens: AOPs and transgenerational effects
- The lack of Transgenerational Inheritance of Anti-androgenic effects after Vinclozolin Treatment
- The potential application of microRNAs in regulatory reproductive toxicology
- Introduction of Percellome Project with special reference to the concept of “signal toxicity” Case study: Single exposure adult studies with developmental cases, at signal dose levels, i.e. at the level of no overt cytotoxicity or organ toxicity monitorable by histopathology
- Mechanisms underlying epigenetic effects of EDCs
- Understand the Relationship Between Epigenetic Change and Adverse Endpoints
- Consensus on what and how?
- What are the general principles for indicating whether the epigenetic change is causal (adverse) or adaptive?
- Practical experience with rodent species used in toxicology studies: what is a normal epigenetic background?
- Determining clear and robust biomarkers of epigenetic change and adversity
- The concept of “repeated exposure” and possible links to epigenetic regulations. Repeated dose studies introducing baseline responses and transient responses with possible link to epigenetics
- Zebrafish Model applications to address what is relevant for multiple generational studies
- How can the Zebrafish Model be applied to current regulatory test paradigms?
- Level Setting: Reproductive Toxicity Studies and Epigenetic Studies
- BREAKOUT GROUP SESSIONS
- CONCLUSIONS AND RECOMMENDATIONS
- ABBREVIATIONS
- BIBLIOGRAPHY
- APPENDIX 1: WORKSHOP PROGRAMME
- APPENDIX 2: LIST OF PARTICIPANTS DAY 1
- APPENDIX 3: LIST OF PARTICIPANTS DAY 2
- APPENDIX 4: Background document
- APPENDIX 5: ORGANISING COMMITTEE
- ECETOC PUBLISHED REPORTS