Special Report 19 PagesSUMMARY PREFACE Definitions INTRODUCTION The value of ontologies The need for a developmental toxicity ontology Purpose of this report AOP/ MOA ONTOLOGY CONCEPT DEFINED RESOURCES FOR BUILDING A DEVELOPMENTAL TOXICITY ONTOLOGY APPROACHES TO BUILDING AN AOP/ MOA ONTOLOGY HOW CAN IT BE DONE? Terminology Specification Ontology development Informal ontologies Natural Language Processing (NLP) Gene Networks CHALLENGES TO BUILDING AND APPLYING AN AOP/ MOA ONTOLOGY Maternal factors Potential MIEs and KEs for building AOPs and IATA for Developmental Toxicity CASE STUDIES FOR AOP DEVELOPMENT Role of Retinoic Acid during Embryogenesis Retinoic Acid and Neural Tube Defects Retinoic Acid and (hind) brain development Conclusions on Case Studies on Retinoic Acid USING TOXCAST TO DEVELOP AOPS ABBREVIATIONS BIBLIOGRAPHY MEMBERS OF THE EXPERT GROUP MEMBERS OF THE SCIENTIFIC COMMITTEE MEMBERS OF THE SCIENTIFIC COMMITTEE (cont’d) HOW CAN IT BE DONE?
