Technical Report 130 PagesSUMMARY 1.INTRODUCTION 2.DEFINITIONS 3.THE STEPS I-VII OF THE ECETOC 7SI-ED 4.EXPLANATORY NOTES TO THE STEPS I-VII OF THE ECETOC 7SI-ED Step I: Gathering of relevant information with regard to adverse effects and endocrine modes-of-action (MoA) Step II: Evaluation of quality, reliability, reproducibility and consistency of the individual studies Step III: Evaluation and summary of the evidence for an adverse effect Step IV: Evaluation and summary of the evidence for endocrine activity Step V: Integration of the evidence and evaluation of biological plausibility that adverse effect and endocrine activity are linked by specific endocrine MoA Step VI: Identification of uncertainties Step VII: Conclusions on endocrine disrupting properties 5.CONCLUSION ABBREVIATIONS BIBLIOGRAPHY APPENDIX A: BACKGROUND INFORMATION Activities of the OECD related to endocrine disruptors Activities of the Commission related to endocrine disruptors Prior ECETOC work related to endocrine disruptors References to Appendix A: Background information APPENDIX B: PROVISIONS IN THE CURRENT PPP AND BP REGULATIONS THAT RELATE TO ENDOCRINE DISRUPTORS Regulation (EC) No 1107/2009 concerning the placing on the market of PPP Commission Regulation (EU) No 283/2013 setting out the data requirements for active substances in accordance with the PPP Regulation Regulation (EU) No 528/2012 concerning the making available on the market and use of BP APPENDIX C: DRAFT COMMISSION REGULATIONS SETTING OUT SCIENTIFIC CRITERIA FOR THE DETERMINATION OF ENDOCRINE DISRUPTING PROPERTIES AND AMENDING THE PPP AND BP REGULATIONS Draft Commission Regulation setting out scientific criteria for the determination of endocrine disrupting properties and amending Annex II to the PPP Regulation Draft Commission Delegated Regulation setting out scientific criteria for the determination of endocrine-disrupting properties pursuant to the BP Regulation MEMBERS OF THE TASK FORCE MEMBERS OF THE TASK FORCE STEERING COMMITTEE MEMBERS OF THE SCIENTIFIC COMMITTEE MEMBERS OF THE SCIENTIFIC COMMITTEE (cont’d) ECETOC PUBLISHED REPORTS ECETOC PUBLISHED REPORTS The full catalogue of ECETOC publications can be found on the ECETOC website: https://www.ecetoc.org/publications
