Technical Report 130
4.EXPLANATORY NOTES TO THE STEPS I-VII OF THE ECETOC 7SI-ED
- Step I: Gathering of relevant information with regard to adverse effects and endocrine modes-of-action (MoA)
- Step II: Evaluation of quality, reliability, reproducibility and consistency of the individual studies
- Step III: Evaluation and summary of the evidence for an adverse effect
- Step IV: Evaluation and summary of the evidence for endocrine activity (and non-endocrine activity, if available)
- Step V: Integration of the evidence and evaluation of biological plausibility that adverse effect and endocrine activity are linked by specific endocrine MoA
- Step VI: Identification of uncertainties
- Step VII: Conclusions on endocrine disrupting properties