ECETOC is an industry-funded expert not-for-profit think tank whose sole purpose is to enhance the quality of chemicals risk assessment so that chemicals management decisions are informed, reliable and safe.

ECETOC works openly and transparently with experts and scientists from industry, regulatory institutions, academia and NGOs worldwide to develop tools and guidance on how emerging science can enhance the efficiency and effectiveness of existing risk assessment frameworks.... read more

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General information:

ECETOC e-newsletter issue 28: Spring 2015

Publications catalogue

ECETOC 2014 Annual Report

Membership benefits: increase the impact of your science




Popular Activities:

Task Forces

Workshops, Symposia and other meetings

Cefic LRI Projects Under ECETOC Management / Leadership

Continuing work on endocrine disrupting chemicals


Board of Administration

Scientific Committee


External links:

Adverse Outcome Pathway Wiki

Latest scientific publications:

Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions. 11-13 February 2014 (Published November 2014 as Workshop Report no.28)

Arts et al. 2014. A Critical Appraisal of Existing Concepts for the Grouping of Nanomaterials.
Regulatory Toxicology and Pharmacology  70(2):492-506
Doi: 10.1016/j.yrtph.2014.07.025  (Open Access)

Hennes† et al. 2014. Incorporating potency into EU classification for carcinogenicity and reproductive toxicity.
Regulatory Toxicology & Pharmacology 70(2):457-467
Doi: 10.1016/j.yrtph.2014.07.022 (Open Access)   [Footnote: † Deceased]

Information to be considered in a weight-of-evidence-based PBT/vPvB assessment of chemicals (Annex XIII of REACH). (Published July 2014 as Special Report no.18)

van Ravenzwaay et al. 2014. Editorial - Epigenetics and chemical safety.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764–765:1-2

Addendum to TR114: Technical Basis for the TRA v3.1 (Published December 2013 as Technical Report no.124)

Endocrine Disrupting Chemicals: Package of ECETOC publications

Health Sciences

Dr Madeleine Laffont
Human Health Scientist

Madeleine joined ECETOC in May 2014 to manage ECETOCs human health activities. Responsibilities include managing task forces, workshops and Cefic LRI projects of relevance to human health toxicology and risk assessment. Task Force topics currently range from consumer exposure assessment and modelling to developing best practice for the normalization and statistical analysis of transcriptomic data from microarrays and high throughput sequencing. Cefic-funded research projects that Madeleine manages include assessing the benefits and risks of chemical grouping and read across to reduce animal testing; improved integrated testing strategies, internal and external exposure modelling, and the role of epigenetics in risk assessment. Madeleine earned her Medical Degree from Imperial College, Faculty of Medicine in 2000. Before studying medicine she was a petrochemical journalist first in Paris and then Hong Kong. Since 2010, she has been an an environmental health project management and communications consultant (Qatar then Belgium). Prior to that, she managed a range of environmental health issues for Cefic (the European Chemical Industry Council) for several years.

Recent human health meetings

05-06 February 2014, Brussels, Belgium: 2014 Science scoping meeting on human health & human exposure in risk assessment

Supporting the Cefic-LRI

Human Health and Exposure Monitoring Team

Recent human health related publications

Environmental Sciences
Malyka Galay Burgos
Dr. Malyka Galay Burgos
Environmental Sciences Manager

As the Environmental Sciences Manager within the secretariat of ECETOC, most of Malyka's work focuses on the current risk assessment and scientific criteria for the limits on the release of chemicals into the environment and the possible effects on human health: multiple stressors, chemical mixture assessment, laboratory to field assessment, structure-activity relationships; mechanisms of exposure and toxicity; sediment and water toxicity, methods and evaluation; risk and hazard assessment; biomarkers; mode of action of metal and xenobiotics; toxicokinetics; factors that modify toxicity; biomonitoring.

For this, she also seeks ways to support the further development and application of alternative approaches to hazard assessment and thereby improve the workability of REACH and good Integrated Testing Strategy (ITS) approaches that reduce costs and the use of animals while providing best quality data for the risk assessment process.

Some of her interests are in strengthening risk assessment through an evolving systems toxicology approach, utilising an understanding of chemical - biological interactions across natural compounds, emerging contaminants and potentially novel marine biotechnologies.

Current Task Forces

Adapting Simple Treat for simulating behaviour of chemical substances

Sufficiency of aquatic hazard information for environmental risk assessment

Chemical risk assessment - ecosystem services

Exploring novel ways of using SSD to establish PNECs for industrial chemicals

Guidance on interpreting endocrine disrupting effects

Targeted risk assessment

Activity-Based Relationships for Aquatic Ecotoxicology Data:  Use of the Activity Approach to Strengthen MoA Predictions

Workshops, Symposia and other meetings




11.Feb.14, Amsterdam, Netherlands: Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions

29-30.Jan.2013: 2014 Environment Progress Review

22-23.Apr.2013, Barcelona, Spain: Expert panel to better understand endocrine disrupter low doses effects

25.Feb.2013, Málaga, Spain: Omics and Risk Assessment Science

Targeted risk assessment (TRA) tools

Targeted Risk Assessment (TRA) Tools - home page

Supporting the Cefic-LRI
Environment Research Liaison Team (Click for more details on the Cefic-LRI projects)
Latest publications

Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions, 11-13 February 2014, Amsterdam (In Press)

Addendum to TR114: Technical Basis for the TRA v3.1 (Published December 2013 as Technical Report no.124)

Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions (Published December 2013 as Technical Report no.120)

van Ravenzwaay B, Dekant W, Vrijhof H. 2013. Risk assessment of endocrine disrupting chemicals – Introduction to this special issue. Toxicology Letters 223(3):269-270.  Doi 10.1016/j.toxlet.2013.10.006

Assessing Environmental Persistence, 6-7 November 2012, Paris (Published December 2013 as Workshop Report no.24)

Expert Panel to better understand Endocrine Disrupter Low Doses Effects 22-23 April 2013, Barcelona (Published October 2013 as Workshop Report no.27)

Scholz et al. 2013. A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology 67(3):506-530. Doi 10.1016/j.yrtph.2013.10.003.

Endocrine Disrupting Chemicals: Package of ECETOC publications on ED

To contact Malyka, please call: +32 2 675 36 00 or send an e-mail to:

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