ECETOC is the leading industry association for developing and promoting top quality science in human and environmental risk assessment of chemicals... read more

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Activities:

Task Forces

Workshops, Symposia and other meetings

Supporting the Cefic LRI

EUROECOTOX (external website)

People / Topics:

Health sciences manager

Environmental sciences manager

Chemicals programme manager

Endocrine disrupting chemicals

General information:

ECETOC e-newsletter no.25: December 2013

Publications catalogue

ECETOC 2012 Annual Report

Membership benefits: increase the impact of your science

ECETOC code of practice


Recent Scientific Reports:

Assessing Environmental Persistence. 6-7 November 2012, Paris (Published December 2013 as Workshop Report no.24)

Environmental Exposure Assessment of Ionisable Organic Compounds (Published December 2013 as Technical Report no.123)

Poorly Soluble Particles / Lung Overload (Published December 2013 as Technical Report no.122)

Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions - Published December 2013 as Technical Report no.120)

Moore et al. 2013. Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS) Critical Reviews in Toxicology 43(10):850-891 (Doi: 10.3109/10408444.2013.854734)

Efficacy and safety of antidotes for acute poisoning by cyanides (2 volumes plus database - Published November 2013 as Technical Report no.121)

Scholz et al. 2013. A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology 67(3):506-530. Doi 10.1016/j.yrtph.2013.10.003.

'Omics and risk assessment science. 25-26 February 2013, Málaga (Published September 2013 as Workshop Report no.25)

Patlewicz et al. 2013. Use of category approaches, read-across and (Q)SAR: General considerations. Regulatory Toxicology and Pharmacology 67(1):1-12. Doi 10.1016/j.yrtph.2013.06.002

Mode of Action: Recent developments, regulatory application and future work. 21-22 February 2013, Vienna (Published June 2013 as Workshop Report no.26)

Evaluation of systemic health effects following dermal exposure to chemicals (Published March 2013 as Technical Report no.119)

Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals (Published June 2013 as Technical Report no.118)

Understanding the relationship between extraction technique and bioavailability (Published June 2013 as Technical Report no.117)

Endocrine Disrupting Chemicals: Package of ECETOC publications

ECETOC‘s approach

ECETOC believes that by identifying developing issues at their nascence, the chemicals industry will be better placed to undertake the appropriate scientific initiatives. An over-arching science strategy serves to guide ECETOC‘s science programme and uses an issues, rather than activity-based approach.

What does it involve?

The premise of this strategy is that ECETOC plays an integral role in science in society. Its particular remit is to contribute objective scientific evidence to the debate about the role of chemicals in the causality of disease and assure the process of risk assessment of these chemicals.

It does so via the pursuit of the following 5 broad themes:

    Presence of chemicals in humans
    Presence of chemicals in the environment
    Effects on humans and ecosystems
    Methods
    Science of risk assessment.

This science strategy is also used as a basis for working with other stakeholders, such as academia, regulators, associations and international institutions to ensure that objective scientific evidence is used to provide the highest quality risk assessment of chemical products that minimises wherever possible the use of animals in testing.

ECETOC currently pursues the following 10 strategic science areas:

Presence of chemicals in humans.

Chemicals in human tissue

Chemicals in human tissue
Objective:
Ensure that the results of biomonitoring studies are placed into appropriate context within risk assessment to human health.

Mixtures

Mixtures and co-exposure
Objective:
Contribute to the development of a pragmatic, realistic, and science-based framework for the risk assessment of chemical mixtures.

Presence of chemicals in the environment

Assessment of environmental fate and behaviour

Assessment of environmental fate and behaviour
Objective:
Develop the understanding of environmental processes that drive the fate and behaviour of chemicals and the role of these processes in risk assessment.

Effects in humans and ecosystems

Reproductive health

Reproductive health
Objective:
Ensure that the methods and the testing strategy to identify and characterise developmental and reproductive toxicants are appropriate and optimised.

Biodiversity and ecosystems

Biodiversity and ecosystems
Objective:
Identify the key science issues relevant to risk assessment of chemicals in the environment in a way that is relevant to the potential impact on biodiversity of aquatic and terrestrial ecosystems.

Methods

Integrated testing strategies Integrated testing strategies
Objective:
Contribute to a more effective approach to hazard and risk assessment. This should also support the further development and application of alternative approaches to hazard assessment, and thereby improve the workability of REACH. Good ITS approaches can reduce cost and use of animals while providing best quality data for the risk assessment process.
Risk assessment of nanomaterials

Risk assessment of nanomaterials
Objective:
Develop a series of approaches for addressing health and environmental effects of nanomaterials.

Science of risk assessment

Role of chemicals in the causality of disease

Role of chemicals in the causality of disease
Objective:
Put the presumed associations between chemicals in the environment and disease into their proper scientific perspective. The focus is particularly directed towards rigorous methodology in observational epidemiology.

Risk, hazard and precaution

Risk, hazard and precaution
Objective:
Take into account all available scientific tools to adequately characterise risk not only based on hazard characteristics but also on exposure data and dose-response considerations.

Science in society

Science in society
Objective:
Improve public confidence in the science of risk assessment and to promote its use in public policy actions. This includes the need to counter the perceptions of bias, vested interest and lack of quality assurance of industry generated data.

 

Health Sciences

Message regarding Christa Hennes


Over the years, many of you will have come to know our human health sciences manager, Christa Hennes as a colleague and as a friend. It is with great sadness that we have to inform you that Christa passed away in December 2013 after a long and brave struggle with her health.

Christa joined ECETOC as Health Sciences Manager in October 2002 and was Scientific Secretary to the ECETOC Scientific Committee. Christa was a wonderful, kind and generous person to work with and will be remembered for her professionalism, dedication and good- natured character. She will be missed very much by her colleagues and we send our deepest and sincerest condolences to her family.

Until a new human health sciences manager can be found, Christa's activities are being managed by ECETOC's Secretary General, Dr Alan Poole

Recent meetings

21-22 February 2013, Vienna, Austria: Mode of Action: Recent developments, regulatory application and future work (in co-operation with WHO-IPCS)

20 June 2012, Stockholm, Sweden: ECETOC session at EUROTOX 2012. Dose-response relationship and receptor-mediated toxicology,

Supporting the Cefic-LRI

Health Effects Monitoring Team

Recent publications


Moore et al. 2013. Guidance on classification for reproductive toxicity under the globally harmonized system of classification and labelling of chemicals (GHS) Critical Reviews in Toxicology 43(10):850-891 (Doi: 10.3109/10408444.2013.854734)

Patlewicz et al. 2013. Use of category approaches, read-across and (Q)SAR: General considerations. Regulatory Toxicology and Pharmacology 67(1):1-12. Doi 10.1016/j.yrtph.2013.06.002

Mode of Action: Recent developments, regulatory application and future work (Published June 2013 as Workshop Report no.26)

Evaluation of systemic health effects following dermal exposure to chemicals (Published March 2013 as Technical Report no.119)

Category approaches, read-across (Q)SAR (Published November 2012 as Technical Report no.116)

Effects of chemical co-exposures at doses relevant for human safety assessments (Published July 2012 as Technical Report no.115)

Hennes EC. 2012. An overview of values for the threshold of toxicological concern. Toxicology Letters 211(3):296–303 doi: 10.1016/j.toxlet.2012.03.795

Hennes et al. 2012. Workshop: Combined exposure to chemicals. Regulatory Toxicology and Pharmacology 63:53-54. doi: 10.1016/j.yrtph.2012.02.008



Environmental Sciences
Malyka Galay Burgos
Environmental Sciences Manager
Dr. Malyka Galay Burgos

As the Environmental Sciences Manager within the secretariat of ECETOC, most of Malyka's work focuses on the current risk assessment and scientific criteria for the limits on the release of chemicals into the environment and the possible effects on human health: multiple stressors, chemical mixture assessment, laboratory to field assessment, structure-activity relationships; mechanisms of exposure and toxicity; sediment and water toxicity, methods and evaluation; risk and hazard assessment; biomarkers; mode of action of metal and xenobiotics; toxicokinetics; factors that modify toxicity; biomonitoring.

For this, she also seeks ways to support the further development and application of alternative approaches to hazard assessment and thereby improve the workability of REACH and good Integrated Testing Strategy (ITS) approaches that reduce costs and the use of animals while providing best quality data for the risk assessment process.

Some of her interests are in strengthening risk assessment through an evolving systems toxicology approach, utilising an understanding of chemical - biological interactions across natural compounds, emerging contaminants and potentially novel marine biotechnologies.

Task Forces

Current

Sufficiency of aquatic hazard information for environmental risk assessment

Chemical risk assessment - ecosystem services

Exploring novel ways of using SSD to establish PNECs for industrial chemicals

Guidance on interpreting endocrine disrupting effects

Targeted risk assessment

Activity-Based Relationships for Aquatic Ecotoxicology Data:  Use of the Activity Approach to Strengthen MoA Predictions

Recently completed

Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals

Understanding the relationship between extraction technique and bioavailability

Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environmentRisk assessment approaches for PBT/vPvB or POPs

Workshops, symposia and other meetings

Upcoming:


Recent:

11.Feb.14, Amsterdam, Netherlands: Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions

29-30.Jan.2013: 2014 Environment Progress Review

22-23.Apr.2013, Barcelona, Spain: Expert panel to better understand endocrine disrupter low doses effects

25.Feb.2013, Málaga, Spain: “Omics and Risk Assessment Science

07-08.Feb.2013: 2013 Environment Progress Review

6.Nov.2012, Paris, France: Assessing Environmental Persistence

03.May.2012, Brussels, Belgium: Targeted risk assesment version 3 workshop

28-29.Feb.2012, Brussels, Belgium: Environment Progress Review

05-06.Dec.2011, Rome, Italy: Epigenetics and chemical safety

EUROECOTOX Network:
http://www.euroecotox.eu/
Targeted risk assessment (TRA) tools

03-May-12: TRAv3 Workshop, Brussels, Belgium Development of version 3 of the TRA Tool

Targeted Risk Assessment (TRA) Tools - home page

Supporting the Cefic-LRI
Environment Monitoring Team (EMT) (Click for more details on the Cefic-LRI projects)
Latest publications

Activity-Based Relationships for Aquatic Ecotoxicology Data:  Use of the Activity Approach to Strengthen MoA Predictions (Published December 2013 as Technical Report no.120)

van Ravenzwaay B, Dekant W, Vrijhof H. 2013. Risk assessment of endocrine disrupting chemicals – Introduction to this special issue. Toxicology Letters 223(3):269-270.  Doi 10.1016/j.toxlet.2013.10.006

Assessing Environmental Persistence, 6-7 November 2012, Paris (Published December 2013 as Workshop Report no.24)

Expert Panel to better understand Endocrine Disrupter Low Doses Effects 22-23 April 2013, Barcelona (Published October 2013 as Workshop Report no.27)

Scholz et al. 2013. A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment. Regulatory Toxicology and Pharmacology 67(3):506-530. Doi 10.1016/j.yrtph.2013.10.003.

'Omics and risk assessment science. 25-26 February 2013, Málaga (Published September 2013 as Workshop Report no.25)

Weltje L, Wheeler JR, Weyers A, Galay-Burgos M. 2013. Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology. Toxicology Letters Special Issue. (In Press)

Fegert I. 2013. ECETOC Firenze workshop on risk assessment of endocrine substances, including the potency concept. Toxicology Letters Special Issue. (In Press)

Lewis RW. 2013. Risk assessment of “Endocrine Substances: Guidance on Identifying Endocrine Disruptors. Toxicology Letters Special Issue. (In Press)

Development of interim guidance for the inclusion of non-extractable residues (NER) in the risk assessment of chemicals (Published June 2013 as Technical Report no.118)

Understanding the relationship between extraction technique and bioavailability (Published June 2013 as Technical Report no.117)

Bars et al. 2012. Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern. Regulatory Toxicology and Pharmacology 64(1):143-154 Doi:10.1016/j.yrtph.2012.06.013
Awarded “Best Published Paper Advancing the Science of Risk Assessment‘ by the American Society of Toxicology (SOT) Risk Assessment Specialty Section (RASS). The paper was published in the Regulatory Toxicology and Pharmacology Journal in 2012 and can be accessed here: http://bit.ly/ecetoc-art-2012-raeac. It builds upon an earlier paper published in 2011 in the same journal.

Endocrine Disrupting Chemicals: Package of ECETOC publications on ED

Bars R, Fegert I, Gross M, Lewis D, Weltje L, Weyers A, Wheeler JR, Galay-Burgos M. 2012. Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern. Regul.Toxicology and Pharmacology. 64(1):143-154 Doi:10.1016/j.yrtph.2012.06.013

Hennes EC, Galay Burgos M, Hamer M, Pemberton M, Travis K, Rodriguez C. 2012. Workshop: Combined exposure to chemicals. Regulatory Toxicology and Pharmacology 63:53-54. Doi: 10.1016/j.yrtph.2012.02.008

ECETOC TRA version 3: Background and Rationale for the Improvements (Published July 2012 as Technical Report no.114)

Epigenetics and Chemical Safety. 5-6 December 2011, Rome (Published May 2012 as Workshop Report no.23)

Risk Assessment of Endocrine Disrupting Chemicals. 9-10 May 2011, Florence (Published October 2011 as Workshop Report no.21)

 

To contact Malyka, please call: +32 2 675 36 00 or send an e-mail to: info@ecetoc.org

Chemicals Programme
Henk Vrijhof
Chemicals Programme Manager
lr. Henk Vrijhof

Please note that Henk retired at the end of January 2014.

Ir. Hendrik (Henk) Vrijhof was a senior staff member and chemicals programme manager at the ECETOC secretariat in Brussels from 1988-2014. He has been scientific secretary of many task forces.

Ir. Vrijhof has a background in environmental sciences (Wageningen University, Netherlands) and worked in national (RIVM) and international (EC, OSPARCOM) government. His interest is in dangerous substances in the environment.

At ECETOC, Ir. Vrijhof has been supporting the series of critical reviews on specific chemicals (Joint Assessment of Commodity Chemicals). In addition, he has co-ordinated various other projects related to toxicogenomics and environmental hazard assessment. He is also secretary of HETRA, the Human Exposure and Tiered Risk Assessment group advising CEFIC-LRI.

Ir. Vrijhof is a member of the Belgian and Dutch professional toxicology and water societies. He has organised a number of symposia together with EEMS, the European Environmental Mutagen Society.

Current task forces
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Supporting the Cefic-LRI
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