ECETOC is an industry-funded expert not-for-profit think tank whose sole purpose is to enhance the quality of chemicals risk assessment so that chemicals management decisions are informed, reliable and safe.

ECETOC works openly and transparently with experts and scientists from industry, regulatory institutions, academia and NGOs worldwide to develop tools and guidance on how emerging science can enhance the efficiency and effectiveness of existing risk assessment frameworks.... read more

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General information:

ECETOC e-newsletter issue 28: Spring 2015

Publications catalogue

ECETOC 2014 Annual Report

Membership benefits: increase the impact of your science

 

 

 

Quicklinks:

Task Forces

Workshops, Symposia and other meetings

Expert Working Groups

Cefic LRI Projects Under ECETOC Management / Leadership

Continuing work on endocrine disrupting chemicals

People:

Board of Administration

Scientific Committee

Secretariat

External links:

Adverse Outcome Pathway Wiki

Latest scientific publications:

Cochrane SA, Arts JHE, Ehnes C, Hindle S, Hollnagel HM, Poole A, Suto H, Kimber I. 2015.
Thresholds in chemical respiratory sensitisation.
Toxicology 333:179-194 (Open Access) Doi 10.1016/j.tox.2015.04.010

Arts J, Hadi M, Irfan MA, Keene AM, Kreiling R, Lyon D, Maier M, Michel K, Petry T, Sauer UG, Warheit D, Wiench K, Wohlleben W, Landsiedel R. 2015.
A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regulatory Toxicology and Pharmacology 71(2):S1-S27 (Open Access) Doi:10.1016/j.yrtph.2015.03.007

Rouquié D, Heneweer M, Botham J, Ketelslegers H, Markell L, Pfister T, Steiling W, Strauss V, Hennes C. 2014.
Contribution of New Technologies to Characterization and Prediction of Adverse Effects.
Critical Reviews in Toxicology 45(2):172-183. Doi:10.3109/10408444.2014.986054

Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions. 11-13 February 2014 (Published November 2014 as Workshop Report no.28)

Arts et al. 2014. A Critical Appraisal of Existing Concepts for the Grouping of Nanomaterials.
Regulatory Toxicology and Pharmacology 70(2):492-506 (Open Access)
Doi: 10.1016/j.yrtph.2014.07.025

Hennes† et al. 2014. Incorporating potency into EU classification for carcinogenicity and reproductive toxicity.
Regulatory Toxicology & Pharmacology 70(2):457-467 (Open Access)
Doi: 10.1016/j.yrtph.2014.07.022   [Footnote: † Deceased]

Information to be considered in a weight-of-evidence-based PBT/vPvB assessment of chemicals (Annex XIII of REACH). (Published July 2014 as Special Report no.18)

van Ravenzwaay et al. 2014. Editorial - Epigenetics and chemical safety.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764–765:1-2
Doi: 10.1016/j.mrgentox.2014.01.008


Human Health Sciences
Malyka Galay Burgos
Dr Madeleine Laffont
Human Health Scientist

Madeleine joined ECETOC in May 2014 to manage ECETOCs human health activities. Responsibilities include managing task forces, workshops and Cefic LRI projects of relevance to human health toxicology and risk assessment. Task Force topics currently range from consumer exposure assessment and modelling to developing best practice for the normalization and statistical analysis of transcriptomic data from microarrays and high throughput sequencing. Cefic-funded research projects that Madeleine manages include assessing the benefits and risks of chemical grouping and read across to reduce animal testing; improved integrated testing strategies, internal and external exposure modelling, and the role of epigenetics in risk assessment. Madeleine earned her Medical Degree from Imperial College, Faculty of Medicine in 2000. Before studying medicine she was a petrochemical journalist first in Paris and then Hong Kong. Since 2010, she has been an an environmental health project management and communications consultant (Qatar then Belgium). Prior to that, she managed a range of environmental health issues for Cefic (the European Chemical Industry Council) for several years.

Current Task Forces

Thresholds in Respiratory Sensitisation

Grouping of Nanomaterials

Guidance for effective use of human exposure data in risk assessment of chemicals

Guidance on conducting the various modules of the extended one-generation reproductive toxicity test (EOGRT)

Workshops and Symposia

Upcoming

24 August 2015, Prague, Czech Republic
ECETOC-sponsored workshop at European Environmental Mutagenesis and Genomics Society (EEMGS) 44th Annual Meeting: Emerging Issues: the use and safety assessment of small RNA molecules

Recent

09 September 2014, Edinburgh, Scotland
EUROTOX 2014,Session organised by ECETOC on the Application of AOP/MOA-Based Approaches in Chemical Risk Assessment

07 July 2014, Lancaster, UK: Symposium at EEMS
Symposium on genotoxicity of nanomaterials

05 February 2014, Brussels, Belgium
2014 Science scoping meeting on human health & human exposure in risk assessment

Expert Working Groups

AOP/MOA of Reproductive Health Ontology

Transcriptomics Analysis Framework

Non-coding RNA

Supporting the Cefic-LRI

Human Health and Exposure Monitoring Team

Recent human health related publications

Cochrane SA, Arts JHE, Ehnes C, Hindle S, Hollnagel HM, Poole A, Suto H, Kimber I. 2015.
Thresholds in chemical respiratory sensitisation.
Toxicology 333:179-194 (Open Access) Doi 10.1016/j.tox.2015.04.010

Arts J, Hadi M, Irfan MA, Keene AM, Kreiling R, Lyon D, Maier M, Michel K, Petry T, Sauer UG, Warheit D, Wiench K, Wohlleben W, Landsiedel R. 2015.
A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping).
Regulatory Toxicology and Pharmacology
71(2):S1-S27 (Open Access) Doi:10.1016/j.yrtph.2015.03.007

Rouquié D, Heneweer M, Botham J, Ketelslegers H, Markell L, Pfister T, Steiling W, Strauss V, Hennes C. 2014.
Contribution of New Technologies to Characterization and Prediction of Adverse Effects.
Critical Reviews in Toxicology 45(2):172-183.
Doi:10.3109/10408444.2014.986054

Hennes C†, Batke M, Bomann W, DuHayon S, Kosemund K, Politano V, Stinchcombe S, Doe J. 2014.
Incorporating potency into EU classification for carcinogenicity and reproductive toxicity.
Regulatory Toxicology & Pharmacology 70(2):457-467 (Open Access)   [Footnote: † Deceased] Doi: 10.1016/j.yrtph.2014.07.022

Arts J, Hadi M, Keene A, Kreiling R, Lyon D, Maier M, Michel K, Petry T, Sauer U, Warheit D, Wiench K, Landsiedel R. 2014.
A Critical Appraisal of Existing Concepts for the Grouping of Nanomaterials.
Regulatory Toxicology and Pharmacology  70(2):492-506 (Open Access)
Doi: 10.1016/j.yrtph.2014.07.025

van Ravenzwaay B, Kleinjans J, Vrijhof H. 2014.
Editorial - Epigenetics and chemical safety
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764–765:1-2
Doi: 10.1016/j.mrgentox.2014.01.008

Thomson J P, Moggs J G, Wolf C R, Meehan R R. 2014.
Epigenetic profiles as defined signatures of xenobiotic exposure.
Mutation research. Genetic toxicology and environmental mutagenesis 764-765:3-9
Doi: 10.1016/j.mrgentox.2013.08.007

Mirbahai L, Chipman J K. 2014.
Epigenetic memory of environmental organisms: A reflection of lifetime stressor exposures.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:10-17
Doi: 10.1016/j.mrgentox.2013.10.003

Cadet J. Wagner J R. 2014.
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.
Mutation research. Genetic toxicology and environmental mutagenesis 764-765:18-35
Doi: 10.1016/j.mrgentox.2013.09.001

Vandegehuchte M B, Janssen C R. 2014.
Epigenetics in an ecotoxicological context.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:36-45
Doi: 10.1016/j.mrgentox.2013.08.008

Siddeek B, Inoubli L, Lakhdari N, Rachel P B, Fussell K C, Schneiderg S, Mauduita C, Benahmed M. 2014.
MicroRNAs as potential biomarkers in diseases and toxicology.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:46-57
Doi: 10.1016/j.mrgentox.2014.01.010

Zarakowska E, Gackowski D, Foksinski M, Olinski R. 2014.
Are 8-oxoguanine (8-oxoGua) and 5-hydroxymethyluracil (5-hmUra) oxidatively damaged DNA bases or transcription (epigenetic) marks?
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:58-63
Doi: 10.1016/j.mrgentox.2013.09.002

Jaksik R, Lalik A, Skonieczna M, Cieslar-Pobuda A, Student S, Rzeszowska-Wolny J. 2014.
MicroRNAs and reactive oxygen species: Are they in the same regulatory circuit?
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:64-71
Doi: 10.1016/j.mrgentox.2013.09.003

Kleinjans J, van Ravenzwaay B. 2014.
Epigenetics and chemical safety – Concluding remarks.
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 764:72-73
Doi: 10.1016/j.mrgentox.2014.03.003

Environmental Sciences
Malyka Galay Burgos
Dr. Malyka Galay Burgos
Environmental Sciences Manager

As the Environmental Sciences Manager within the secretariat of ECETOC, most of Malyka's work focuses on the current risk assessment and scientific criteria for the limits on the release of chemicals into the environment and the possible effects on human health: multiple stressors, chemical mixture assessment, laboratory to field assessment, structure-activity relationships; mechanisms of exposure and toxicity; sediment and water toxicity, methods and evaluation; risk and hazard assessment; biomarkers; mode of action of metal and xenobiotics; toxicokinetics; factors that modify toxicity; biomonitoring.

For this, she also seeks ways to support the further development and application of alternative approaches to hazard assessment and thereby improve the workability of REACH and good Integrated Testing Strategy (ITS) approaches that reduce costs and the use of animals while providing best quality data for the risk assessment process.

Some of her interests are in strengthening risk assessment through an evolving systems toxicology approach, utilising an understanding of chemical - biological interactions across natural compounds, emerging contaminants and potentially novel marine biotechnologies.

Current Task Forces

Assessing aquatic toxicity and bioaccumulation of sparingly soluble substances and manufactured nanomaterials (in preparation)

Freshwater Ecotoxicity as an environmental impact category to guide the selection of chemical-based products

Exploring community-based environmental hazard assessments of mixtures based on mode-of-action based approaches

Adverse Outcome Pathways (AOPs) focusing on endocrine active chemicals

Adapting Simple Treat for simulating behaviour of chemical substances

Sufficiency of aquatic hazard information for environmental risk assessment

Chemical risk assessment - ecosystem services

Exploring novel ways of using SSD to establish PNECs for industrial chemicals

Guidance on interpreting endocrine disrupting effects

Targeted Risk Assessment Tool (TRA) Steering Team

Activity-Based Relationships for Aquatic Ecotoxicology Data:  Use of the Activity Approach to Strengthen MoA Predictions

Workshops, Symposia and other meetings

Upcoming:

29-30 October 2015, Snowbird Resort, Utah, USA
Defining the role of chemical activity in environmental risk assessment within the context of mode of action: Practical guidance and advice

6 October 2015, Dübendorf (Switzerland)
Identifying limitations of the OECD water-sediment test (OECD 308) and developing suitable alternatives to assess persistence

Recent:

17-18 February 2015, Lowestoft, UK
Workshop on the improvement of the OECD 306 screening test

12-13 February 2015, Brussels, Belgium
2015 ECETOC Environment and LRI Progress Review
EUROECOTOX Network:
http://www.euroecotox.eu/
Targeted risk assessment (TRA) tools

Targeted Risk Assessment (TRA) Tools - home page

Supporting the Cefic-LRI
Environment Research Liaison Team (Click for more details on the Cefic-LRI projects)
Latest Environment-related publications

Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions, 11-13 February 2014, Amsterdam (Published November 2014 as Workshop Report no.28)

Addendum to TR114: Technical Basis for the TRA v3.1 (Published December 2013 as Technical Report no.124)

Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions (Published December 2013 as Technical Report no.120)

van Ravenzwaay B, Dekant W, Vrijhof H. 2013. Risk assessment of endocrine disrupting chemicals – Introduction to this special issue. Toxicology Letters 223(3):269-270.  Doi 10.1016/j.toxlet.2013.10.006

Assessing Environmental Persistence, 6-7 November 2012, Paris (Published December 2013 as Workshop Report no.24)



To contact Malyka, please call: +32 2 675 36 00 or send an e-mail to: info@ecetoc.org

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