TR 138 – ECETOC Guidance on Dose Selection

In a Nutshell

There isn’t any scientific justification for selecting high doses of chemicals in animal tests which could result in lethality, pain, suffering, or other forms of profound toxicity in any of the experimental subjects, according to a new Technical Report from the Centre for chemical safety assessment (ECETOC). Chemical testing requirements to ensure human safety vary by sector, product type and geographical region or country and many require repeat-dose animal tests. The Task Force’s report provides guidance to achieve a good balance between chemical safety assessment requirements and animal welfare, while also supporting the appropriate design and interpretation of toxicity studies.