Article
22.01.2025
Use and limitations of clinical data in the identification and classification of low molecular weight chemicals (LMWCs) as respiratory sensitizers: recommendations for improvement
In a Nutshell
Chemicals are classified to highlight health risks like respiratory sensitisation, where repeated exposure can trigger allergic reactions. In the absence of standard methods, current assessments often rely on human clinical data. However, clinical approaches have not been designed for the classification of chemicals, and use of such approaches may lead to misclassifications and improper risk management. Experts have reviewed the state of the science and highlighted opportunities for better approaches and methods to assess and classify low molecular weight chemicals (LMWCs). The recommendations made aim to allow more accurate identification of respiratory sensitisers and facilitate improved risk management in this important area of human health protection.