EPAA and NC3Rs final call for data: acute oral toxicity studies
ECETOC is supporting this call for data for acute oral toxicity studies. In collaboration with the European Partnership for Alternative Approaches to Animal Testing (EPAA), the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) request access to study reports for acute oral toxicity studies, in order to develop a database of clinical signs observed during these studies.
The data will be analysed and used to develop more objective guidance on the use of ‘evident toxicity’ as an endpoint within the Fixed Dose Procedure (FDP, OECD Test Guideline 420) to support wider use of this test guideline. This test uses fewer animals than other accepted methods and does not use death as an endpoint, giving clear animal welfare benefits.
A significant number of studies have already been collected, but there is still time to contribute to this project! Data contributors will be invited to participate in discussions on the analysis and resulting recommendations.
Please contact Fiona Sewell (email@example.com) by 31 August 2020 for more information.