Noncoding RNAs and Risk Assessment Science

03-04 March 2016, Malaga, Spain

Background

Noncoding RNAs are now known to be involved in post transcriptional gene silencing, epigenetic regulation and mediation of physical and chemical environmental signals. However, although knowledge of how chemical stressors can influence the functionality of ncRNAs is growing, the potential role of ncRNAs in chemicals risk assessment is unclear. This workshop intends to reach a common understanding on the current and potential future role of ncRNAs in toxicology and risk assessment – and develop a prioritised research agenda for research over the next 2-3 years in this regard.

Objectives of the workshop

Day 1 consisted of a series of talks and case studies with room for questions, focussing on:

• Understanding ncRNAs: their physiology, mechanisms of action, functional relevance and possible role in human pathology.

• Understand relevance of ncRNA in toxicology and risk assessment of chemicals

Day 2 consisted of brainstorming activity in which participants worked in breakout groups to:

• Get clarity on data analysis and data interpretation: what is relevant for toxicology and risk assessment?

• Assess whether current toxicology and chemicals risk assessment should be re-evaluated in light of current knowledge of ncRNA

• Develop a prioritised research agenda

Outcome

Paper:
Aigner et al, 2016

ECETOC Workshop Report:
In a nutshell – Noncoding RNAs and Risk Assessment Science
ECETOC WR 32. Noncoding RNAs and Risk Assessment Science

 

 

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