ECETOC Publication Highlights Scientific Perspectives on Developmental Neurotoxicity Testing and Future Regulatory Directions
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ECETOC Publication Highlights Scientific Perspectives on Developmental Neurotoxicity Testing and Future Regulatory Directions

Brussels, 1 October 2026 – ECETOC is pleased to announce the publication of a new review article in Archives of Toxicology titled “Scientific Perspectives on In Vivo Developmental Neurotoxicity T...
Welcome to Talia Neal-Walthall
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Welcome to Talia Neal-Walthall

We are pleased to welcome Talia Neal-Walthall to ECETOC as a secondee. Talia joins us to work on topics related to exposure, an area central to much of our current scientific programme. She will be wi...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
News
07.07.2009

Launch of the new ECETOC targeted risk assessment tools

ECETOC's TRA task force was re-convened in 2006 with the aim of reviewing the current basis for the approach and making recommendations for further improvements. At the same time, the value of the TRA was recognised under the Commission's REACH Implementation Project (RIP) 3.2 stakeholder review activity on the development of chemical safety assessments.

Specifically, the TRA was seen to be the preferred approach for evaluating worker health risks (atthe Tier 1 level) and having the potential for also being adopted for evaluating consumer health risks. At the same time, the task force recognised the need to develop a more workable and pragmatic approach to environmental risk assessment using the principles laid down within the EUSES model. Many of the concepts demonstrated in the original TRA and outlined in the interim TRA webtool scoping/requirements document (insert link) are now incorporated into the planned ECHA CSA/CSR tool (CSAT). Furthermore, the specification for the CSAT foresees integrating the use of several elements of the TRA exposure estimation models.

The TRA task force have therefore sought to develop improved exposure estimation models for workers, consumer and the environment that continue to carry forward the principles that were pioneered in the original TRA web tool whilst accommodating many helpful suggestions from the stakeholder process. The revised TRA consists of 3 distinct exposure estimation models, covering workers, consumers and the environment, supported by a single integrated version of all 3 models (which is technically identical to each model but which introduces work process efficiencies for multiple data entries). Each model is downloadable through the ECETOC website.

A supporting ECETOC Technical Report that describes in detail the current structure of and basis for the revised TRA approach (for workers, consumers and the environment) will be available shortly.