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We’re Hiring: Join the ECETOC Team as a Trainee!

Are you passionate about science, regulatory toxicology, and making a real-world impact at the intersection of industry, academia, and policy? ECETOC is excited to announce that we’re looking for a...
Understanding the influence of time in biology for NGRA
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Understanding the influence of time in biology for NGRA

Brussels, 9 October 2024 – In the transition from in vivo to in vitro toxicity testing, the influence of time has so far not received much attention. Therefore, the Centre for chemical safety asses...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Environment branch

TRA Task Force – Environment branch

This Task Force is active on a number of initiatives:A state of the science literature review on assessment of humans exposed indirectly via the environment, to ascertain the state of the s...
TRA Task Force – Consumer branch

TRA Task Force – Consumer branch

This Task Force was established to carry out an in-depth evaluation of the TRA Consumer tool.A manuscript entitled An assessment of the ECETOC TRA Consumer tool performance as a screening level tool w...
TRA Task Force – Worker branch

TRA Task Force – Worker branch

This Task Force has been active since 2019 to conduct a review of published validation studies on the TRA Worker tool.A peer-reviewed publication (Urbanus et al., 2020) sets out the initial review...
In The Press
03.12.2014

ECETOC workshop addresses aquatic toxicity using species sensitivity distribution

Brussels, December 2014

Predicting the toxicity of chemicals to aquatic communities is an integral element in environmental risk assessment. It is therefore a major component in environmental protection strategies and in the process of managing the safe use and disposal of chemicals.  Hazard (toxicity) is most frequently predicted using concentration–effect data from single species toxicity tests which measure effects on individuals. However, the protection goals are generally wider i.e. populations, communities and ecosystems. Species sensitivity distributions, SSDs, describe the statistical distribution of species sensitivity to a toxicant and so can predict hazardous concentrations (HCps) affecting a certain percentage (p) of all the species in a community. Estimated HCps for environmental protection are usually the 5th percentile of the distribution and are used to derive a protective threshold concentration for an ecosystem.

ECETOC and the Environment Agency for England organised a three day workshop to discuss and review current statistical SSD models, when and how they should be used in regulatory applications and their ecological significance. A number of recommendations were made on how SSD methods could be further developed to improve the quality of decisions needed from both the prospective risk and retrospective impact assessment of chemicals.

The document is published as ECETOC Workshop Report No.28: Estimating toxicity thresholds for aquatic ecological communities from sensitivity distributions. 11-13 February 2014.