Chronos and Kairos – Understanding time in biology: Time4NGRA

This workshop explored the need and approaches to study the influence of time and level of biological organization (population, organism, tissues, cells etc.) in toxicity testing in next generation risk assessment based on new approach methodologies (NAMs). Notably, the aim was to discuss how to integrate the influence of exposure time window, duration, frequency and damage accrual rate in developing and interpreting in vitro models, quantitative adverse outcome pathways (qAOP) and quantitative in vitro to in vivo extrapolation (QIVIVE), while computational models allow us to reduce toxicity readout ‘noise’ due to exposure and observation timing and visualize and interpret the intricacies of toxicity development.

The workshop brought together toxicologists, biologists, bioinformaticians, modelers and risk assessors to support the discussion around the concept of time in human toxicology. This interdisciplinary setting is essential to achieve and provide a forum for experimentalists to meet with modelers to map out how the future of chemical safety assessment can exploit knowledge of the effect of time on toxicity. In so doing, we aim to develop a strategy for including ‘time - variables’ in next-generation risk assessment.

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Click here to download the presentations.