Welcome to Talia Neal-Walthall
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Welcome to Talia Neal-Walthall

We are pleased to welcome Talia Neal-Walthall to ECETOC as a secondee. Talia joins us to work on topics related to exposure, an area central to much of our current scientific programme. She will be wi...
September 2026 news from the Sec Gen
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September 2026 news from the Sec Gen

Dear members and colleagues,As we move through the year, there is a good deal to share. This has been a busy period for ECETOC, with changes to our team, our governance, and the work ahead. Let me...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....

Immunotoxicity-NeurotoxicityDevelopmental neurotoxicity (DNT)

Publications

Thresholds in chemical respiratory sensitisation
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Thresholds in chemical respiratory sensitisation

Brussels, May 2015 A variety of chemicals are known to cause allergic sensitisation of the respiratory tract associated with allergic rhinitis and asthma. It is generally accepted that the development...
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TR 095 Vol II – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II – Substance Profiles

TR 095 Vol II : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II - Substance Profiles | March 2005 This report provides an update of an earlier ECETOC reviewa<...
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TR 095 Vol I – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I

TR 095 Vol I : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I | March 2005 This report provides an update of an earlier ECETOC reviewa of a number of im...
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TR 081 – Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy

TR 081 : Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy | November 2001 The industrial chemical monochloroacetic acid (MCAA) is used mainly in carboxylation reactions. It...
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TR 077 – Skin and Respiratory Sensitisers: Reference Chemical Data Bank

TR 077 : Skin and Respiratory Sensitisers: Reference Chemical Data Bank | August 1999 Certain chemicals can cause occupational and consumer health problems, such as allergic contact dermatitis and al...
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TR 075 – Organophosphorus Pesticides and Long-term Effects on the Nervous System

TR 075 : Organophosphorus Pesticides and Long-term Effects on the Nervous System | December 1998 Organophosphorus pesticides (OPps) have been used for decades. In view of their potent biological effe...
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TR 070 – Chronic Neurotoxicity of Solvents

TR 070 : Chronic Neurotoxicity of Solvents | February 1996 This review addresses the question whether a discrete specific neurological syndrome that is casually related to chronic low-level exposure...
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Monograph 021 – Immunotoxicity: Hazard Identification and Risk Characterisation

Mono 021 : Immunotoxicity: Hazard Identification and Risk Characterisation | September 1994...
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Special Report 06 – Interpretation – Evaluation of the Neurotoxic Potential of Chemicals in Animals

SR 06 : Interpretation - Evaluation of the Neurotoxic Potential of Chemicals in Animals | December 1993...

Task Forces

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...