2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation.Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why?REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
Event
18.02.2025

Webinar: Advancing Best Practices in DART Dose Selection

Since 2019, the ECETOC Dose Selection Task Force has been advancing best practices in dose-setting for toxicity studies. In 2024, their latest recommendations on dose selection for developmental and reproductive toxicity (DART) studies were published (Lewis et al., 2024), building on earlier work (TR 138Sewell et al., 2022). 

This webinar explored critical insights, including how the team integrated regulatory guidance, animal welfare considerations, and cutting-edge science and reflected on key dialogues since the publication, like the 2024 EUROTOX satellite event on DART dose selection, outlining next steps for progress in this vital field. 

Watch the video here

Time (CET) Content Speaker 
17:00-17:05 Welcome and introduction ECETOC 
17:05-17:20 Background and main findings/recommendations  Sue Marty (Dow)
17:20-17:35 Key dialogues since the publication and next steps Fiona Sewell (NC3Rs) 

Find out more
https://www.youtube.com/watch?v=UatOYhDCyfM