2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation.Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Article
10.07.2014

ED Pack – ECETOC publications on endocrine disrupting chemicals (updated 10 July 2014)

Publisher :

This is the updated version of the package of ECETOC publications relating to endocrine disrupting chemicals originally published in October 2012.

It comprises:

Report commissioned by ECETOC

Exponent Review and Comments on the Draft SAAED Report (May 2012)

ECETOC Technical Report

ECETOC TR 106. Guidance on Identifying Endocrine Disrupting Effects (June 2009)

ECETOC Workshop Reports

ECETOC WR 16 & Addendum. Guidance on interpreting endocrine disrupting effects. 29-30 June 2009, Barcelona (Published October 2009)

ECETOC WR 21. Risk assessment of endocrine disrupting chemicals. 9-10 May 2011, Florence (Published November 2011)

ECETOC WR 27. Expert Panel to better understand endocrine disrupter low doses effects. 22-23 April 2013, Barcelona (Published October 2013)&

ECETOC endocrine-related journal publications (Please note that for copyright reasons these are links to the publication web pages to purchase the articles; exceptions are articles listed as open access)

Bars R, Broeckaert F, Fegert I, Gross M, Hallmark N, Kedwards T, Lewis D, O?Hagan S, Panter G H, Weltje L, Weyers A, Wheeler J R, Galay Burgos M. 2011.
Science based guidance for the assessment of endocrine disrupting properties of chemicals.
Regulatory Toxicology and Pharmacology 59(1):37-46.
http://dx.doi.org/10.1016/j.yrtph.2010.09.003

Bars R, Broeckaert F, Fegert I, Gross M, Hallmark N, Kedwards T, Lewis D, O?Hagan S, Panter G H, Weltje L, Weyers A, Wheeeler J and Galay Burgos M. 2011.
Corrigendum to "Science based guidance for the assessment of endocrine disrupting properties of chemicals?.
Regulatory Toxicology and Pharmacology 59:37-46. (Open Access Article - free download link)
http://dx.doi.org/10.1016/j.yrtph.2011.04.005

Bars R, Fegert I, Gross M, Lewis D, Weltje L, Weyers A, Wheeler JR, Galay-Burgos M. 2012.
Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern.
Regulatory Toxicology and Pharmacology 64(1):143-154. (Open Access Article - free download link)
http://dx.doi.org/10.1016/j.yrtph.2012.06.013

van Ravenzwaay B, Dekant W, Vrijhof H. 2013.
Risk assessment of endocrine disrupting chemicals ? Introduction to this special issue.
Toxicology Letters 223(3):269-270.
http://dx.doi.org/10.1016/j.toxlet.2013.10.006

Lewis RW. 2013.
Risk assessment of ?Endocrine Substances: Guidance on Identifying Endocrine Disruptors.
Toxicology Letters 223(3):287-290
http://dx.doi.org/10.1016/j.toxlet.2013.09.001

Weltje L, Wheeler JR, Weyers A, Galay-Burgos M. 2013.
Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology.
Toxicology Letters 223(3):291-294
doi: 10.1016/j.toxlet.2013.02.019

Fegert I. 2013.
ECETOC florence workshop on risk assessment of endocrine substances, including the potency concept.
Toxicology Letters 223(3):310-314
doi: 10.1016/j.toxlet.2013.03.027