Workshop Report 32

BIBLIOGRAPHY

Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Győrffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ. 2016. miR-34a silences c-SRC to attenuate tumor growth in triple-negative breast cancer. Cancer Res 76:927-939.

Akinjo OO, Gant TW, Marczylo EL. 2016. Perturbation of epigenetic processes by doxorubicin in the mouse testis. Toxicol Res 5(4):1129-1243.

Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR, Nichols JW, Russom CL, Schmieder PK, Serrrano JA, Tietge JE, Villeneuve DL. 2010. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment. Env Toxicol Chem 29:730–741.

Arrigo P, Pulliero A. 2015. Effect of environmental chemical stress on nuclear noncoding RNA Involved in epigenetic control. Biomed Res Int 2015:761703.

Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP. 2008. The impact of microRNAs on protein output. Nature 455(7209):64-71.

Baier SR, Nguyen C, Xie F, Wood JR, Zempleni J. 2014. MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers. J Nutr 144(10):1495-1500.

Baker M. 2010. MicroRNA profiling: separating signal from noise. Nat Methods 7:687-692.

Bartel DP. 2009. MicroRNAs: target recognition and regulatory functions. Cell 136:215-233.

Bauer T, Trump S, Ishaque N, Thürmann L, Gu L, Bauer M, Bieg M, Gu Z, Weichenhan D, Mallm JP, Röder S, Herberth G, Takada E, Mücke O, Winter M, Junge KM, Grützmann K, Rolle-Kampczyk U, Wang Q, Lawerenz C, Borte M, Polte T, Schlesner M, Schanne M, Wiemann S, Geörg C, Stunnenberg HG, Plass C, Rippe K, Mizuguchi J, Herrmann C, Eils R, Lehmann I. 2016. Environment-induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children. Mol Syst Biol 12(3):861.

Bhan A, Hussain I, Ansari KI, Bobzean SA, Perrotti LI, Mandal SS. 2014. Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol 141:160-170.

Boll K, Reiche K, Kasack K, Mörbt N, Kretzschmar AK, Tomm JM, Verhaegh G, Schalken J, von Bergen M, Horn F, Hackermüller J. 2013. MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma. Oncogene 32:277-285.

Brocke-Heidrich K, Kretzschmar AK, Pfeifer G, Henze C, Löffler D, Koczan D, Thiesen HJ, Burger R, Gramatzki M, Horn F. 2004. Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Blood 103:242-251.

Calin GA, Croce CM. 2006. MicroRNA signatures in human cancers. Nat Rev Cancer 6(11):857-866.

Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY. 2008. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18:997-1006.

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. 2015. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature 518:107-110.

Chiang VS. 2014. Post-harvest consideration factors for microRNA research in cellular, tissue, serum and plasma samples. Cell Biol Int 38:1345-1354.

Chin LJ, Slack FJ. 2008. A truth serum for cancer – microRNAs have major potential as cancer biomarkers. Cell Res 18:983-984.

Croce CM. 2010. LINCing chromatin remodeling to metastasis. Nat Biotechnol 28:931-932.

Dai X, Tan C. 2015. Combination of microRNA therapeutics with small-molecule anticancer drugs: mechanism of action and co-delivery nanocarriers. Adv Drug Deliv Rev 81:184-197.

Della Vedova CB, Lorbiecke R, Kirsch H, Schulte MB, Scheets K, Borchert LM, Scheffler BE, Wienand U, Cone KC, Birchler JA. 2005. The dominant inhibitory chalcone synthase allele C2-Idf (inhibitor diffuse) from Zea mays (L.) acts via an endogenous RNA silencing mechanism. Genetics 170:1989-2002.

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, Lagarde J, Veeravalli L, Ruan X, Ruan Y, Lassmann T, Carninci P, Brown JB, Lipovich L, Gonzalez JM, Thomas M, Davis CA, Shiekhattar R, Gingeras TR, Hubbard TJ, Notredame C, Harrow J, Guigó R. 2012. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res 22(9):1775-1789.

Dickinson B, Zhang Y, Petrick JS, Heck G, Ivashuta S, Marshall WS. 2013. Lack of detectable oral bioavailability of plant microRNAs after feeding in mice. Nature Biotechnol 31:965-967.

Dueck A, Meister G. 2014. Assembly and function of small RNA – argonaute protein complexes. Biol Chem 395(6):611-629.

Ebert MS, Sharp PA. 2010. Emerging roles for natural microRNA sponges. Curr Biol 20(19):R858-R861.

Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK, Marcucci G, Calin GA, Huebner K, Croce CM. 2007. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA 104:15805-15810.

Floris I, Descamps B, Vardeu A, Mitić T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C. 2015. Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2. Arterioscler Thromb Vasc Biol 35:664-674.

Friedman RC, Farh KK, Burge CB, Bartel DP. 2009. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92-105.

Frizzi A, Zhang Y, Kao J, Hagen C, Huang S. 2014. Small RNA profiles from virus-infected fresh market vegetables. J Agric Food Chem 62:12067-12074.

Gant TW, Marczylo EL, Leonard MO. 2015. Discovery and application of novel biomarkers. In Pfannkuch F, Suter-Dick L, eds, Predictive toxicology: from vision to reality, 1st ed. Wiley-VCH Verlag, Weinhem, Germany.

Gapp K, Jawaid A, Sarkies P, Bohacek J, Pelczar P, Prados J, Farinelli L, Miska E, Mansuy IM. 2014. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat Neurosci 17:667-669.

Gooderham NJ, Koufaris C. 2014. Using microRNA profiles to predict and evaluate hepatic carcinogenic potential. Toxicol Lett 228:127-132.

Greathouse KL, Bredfeldt T, Everitt JI, Lin K, Berry T, Kannan K, Mittelstadt ML, Ho SM, Walker CL. 2012. Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. Mol Canc Res 10:546-557.

Grünweller A, Hartmann RK. 2016. Chemical modification of nucleic acids as a key technology for the development of RNA-based therapeutics. Pharmazie 71:8-16.

Hackermüller J, Reiche K, Otto C, Hösler N, Blumert C, Brocke-Heidrich K, Böhlig L, Nitsche A, Kasack K, Ahnert P, Krupp W, Engeland K, Stadler PF, Horn F. 2014. Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs. Genome Biol 15:R48.

Hannon GJ, Rossi JJ. 2004. Unlocking the potential of the human genome with RNA interference. Nature 431:371-378.

He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. 2005. A microRNA polycistron as a potential human oncogene. Nature 435(7043):828-833.

Hentze MW, Preiss T. 2013. Circular RNAs: splicing’s enigma variations. EMBO J 32(7):923-925.

Huntzinger E, Izaurralde E. 2011. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat Rev Genet 12(2):99-110.

Ivashuta SI, Petrick JS, Heisel SE, Zhang Y, Guo L, Reynolds TL, Rice JF, Allen E, Roberts JK. 2009. Endogenous small RNAs in grain: semi-quantification and sequence homology to human and animal genes. Food Chem Toxicol 47:353-360.

Jain K, Suryakumar G, Ganju L, Singh SB. 2014. Differential hypoxic tolerance is mediated by activation of heat shock response and nitric oxide pathway. Cell Stress Chaperones 19:801-812.

Jensen PD, Zhang Y, Wiggins BE, Petrick JS, Zhu J, Kerstetter RA, Heck GR, Ivashuta SI. 2013. Computational sequence analysis of predicted long dsRNA transcriptomes of major crops reveals sequence complementarity with human genes. GM Crops Food 4:90-97.

Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, Wilson M, Wang X, Shelton J, Shingara J, Chin L, Brown D, Slack FJ. 2007. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res 67:7713-7722.

Jonas S, Izaurralde E. 2015. Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet 16(7):421-433.

Jose AM. 2015. Movement of regulatory RNA between animal cells. Genesis 53:395-416.

Juliano R, Bauman J, Kang H, Ming X. 2009. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol Pharmaceut 6:686-695.

Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermüller J, Hofacker IL, Bell I, Cheung E, Drenkow J, Dumais E, Patel S, Helt G, Ganesh M, Ghosh S, Piccolboni A, Sementchenko V, Tammana H, Gingeras TR. 2007. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Sci 316(5830):1484-1488.

Kasinski AL, Slack FJ. 2011. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev Cancer 11:849-864.

Kato M, Paranjape T, Müller RU, Nallur S, Gillespie E, Keane K, Esquela-Kerscher A, Weidhaas JB, Slack FJ. 2009. The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells. Oncogene 28:2419-2424. Erratum in: Oncogene 28:3008, 2009.

Kim VN. 2005. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 6:376-385.

Klase Z, Kale P, Winograd R, Gupta MV, Heydarian M, Berro R, McCaffrey T, Kashanchi F. 2007. HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR. BMC Mol Biol 8:63.

Koseki M, Goto K, Masuta C, Kanazawa A. 2005. The star-type color pattern in Petunia hybrida ‘red Star’ flowers is induced by sequence-specific degradation of chalcone synthase RNA. Plant Cell Physiol 46:1879-1883.

Koufaris C, Wright J, Currie RA, Gooderham NJ. 2012. Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. Toxicol Sci 128:532-543.

Koufaris C, Gooderham NJ. 2013. Are differences in microRNA regulation implicated in species-dependent response to toxicological exposures? Toxicol Sci 131:337-342.

Koufaris C, Wright J, Osborne M, Currie RA, Gooderham NJ. 2013. Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. Toxicol 314:247-253.

Kowalski MP, Krude T. 2015. Functional roles of non-coding Y RNAs. Int J Biochem Cell Biol 66:20-9.

Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF, Fare TL, Sistare FD, Glaab WE. 2009. Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury. Clin Chem 55(11):1977-1983.

Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. 2008. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 141:672-145.

Lin S, Gregory RI. 2014. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol 16:129-131.

Ling H, Fabbri M, Calin GA. 2013. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 12:847-865.

Liu WM, Pang RT, Chiu PC, Wong BP, Lao K, Lee KF, Yeung WS. 2012. Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci USA 109:490-494.

Löffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermüller J, Kretzschmar AK, Burger R, Gramatzki M, Blumert C, Bauer K, Cvijic H, Ullmann AK, Stadler PF, Horn F. 2007. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood 110:1330-1333.

Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. 2005. MicroRNA expression profiles classify human cancers. Nature 435:834-838.

Lundin KE, Gissberg O, Smith CI. 2015. Oligonucleotide therapies: the past and the present. Hum Gene Ther 26:475-485.

Marczylo EL, Amoako AA, Konje JC, Gant TW, Marczylo TH. 2012. Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern? Epigenetics 7:432-439.

Marczylo EL, Jacobs MN, Gant TW. 2016. Environmentally-induced epigenetic toxicity: potential public health concerns. Crit Rev Toxicol, DOI: 10.1080/10408444.2016.1175417.

Martens-Uzunova ES, Olvedy M, Jenster G. 2013. Beyond microRNA – Novel RNAs derived from small non-coding RNA and their implication in cancer. Cancer Lett 340:201–211.

Martinez J, Patkaniowska A, Urlaub H, Lührmann R, Tuschl T. 2002. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110:563-574.

Meister G. 2013. Argonaute proteins: functional insights and emerging roles. Nat Rev Genet 14:447-459.

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M. 2008. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105:10513-10518.

Mlotshwa S, Pruss GJ, MacArthur JL, Endres MW, Davis C, Hofseth LJ, Peña MM, Vance V. 2015. A novel chemopreventive strategy based on therapeutic microRNAs produced in plants. Cell Res 25:521-524.

Moazed D. 2009. Small RNAs in transcriptional gene silencing and genome defence. Nature 457:413-420.

O’Neill MJ, Bourre L, Melgar S, O’Driscoll CM. 2011. Intestinal delivery of non-viral gene therapeutics: Physiological barriers and preclinical models. Drug Discovery Today 16:203-218.

OECD. 2012. Appendix I. Collection of working definitions. Available at:

http://www.oecd.org/chemicalsafety/testing/49963576.pdf.

Petrick JS, Brower-Toland B, Jackson AL, Kier LD. 2013. Safety assessment of food and feed from biotechnology-derived crops employing RNA-mediated gene regulation to achieve desired traits: a scientific review. Regul Toxicol Pharmacol 66:167-176.

Petrick JS, Moore WM, Heydens WF, Koch MS, Sherman JH, Lemke SL. 2015. A 28-day oral toxicity evaluation of small interfering RNAs and a long double-stranded RNA targeting vacuolar ATPase in mice. Regul Toxicol Pharmacol 71:8-23.

Pritchard CC, Cheng HH, Tewari M. 2012. MicroRNA profiling: approaches and considerations. Nat Rev Genet 13:358-369.

Rinn JL, Chang HY. 2012. Genome regulation by long noncoding RNAs. Annu Rev Biochem 81:145-166.

Rodgers AB, Morgan CP, Bronson SL, Revello S, Bale TL. 2013. Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J Neurosci 33:9003-9012.

Rodgers AB, Morgan CP, Leu NA, Bale TL. 2015. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proc Natl Acad Sci USA 112:13699-13704.

Russell WMS, Burch RL. 1959. The principles of humane experimental technique. London, UK. Methuen. Reprinted by UFAW (1992): 8 Hamilton Close, South Mimms, Potters Bar, Herts EN6 3QD England. 238 pp.

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. 2011. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 146:353-358.

Schmidt K, Schmidtke J, Kohl C, Wilhelm R, Schiemann J, van der Voet H, Steinberg P. 2016. Enhancing the interpretation of statistical P values in toxicology studies: implementation of linear mixed models (LMMs) and standardized effect sizes (SESs). Arch Toxicol 90:731-51.

Schraivogel D, Meister G. 2014. Import routes and nuclear functions of Argonaute and other small RNA-silencing proteins. Trends Biochem Sci 39:420-431.

Schramedei K, Mörbt N, Pfeifer G, Läuter J, Rosolowski M, Tomm JM, von Bergen M, Horn F, Brocke-Heidrich K. 2011. MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. Oncogene 30:2975-2985.

Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N. 2008. Widespread changes in protein synthesis induced by microRNAs. Nature 455:58-63.

Singh MS, Peer D. 2016. RNA nanomedicines: the next generation drugs? Curr Opin Biotechnol 39:28-34.

Snow JW, Hale A, Isaacs SK, Baggish AL, Chan SY. 2013. Ineffective delivery of diet-derived microRNAs to recipient animal organisms. RNA Biol 10:1107-1116.

Stowe HM, Calcatera SM, Dimmick MA, Andrae JG, Duckett SK, Pratt SL. 2014. The bull sperm microRNAome and the effect of fescue toxicosis on sperm microRNA expression. PLoS One 9:e113163.

Tonge DP, Gant TW. 2016. What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme. BMC Mol Biol 17:4.

Tosar JP, Gámbaro F, Sanguinetti J, Bonilla B, Witwer KW, Cayota A. 2015. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res 43:5601-5616.

Trerotola M, Relli V, Simeone P, Alberti S. 2015. Epigenetic inheritance and the missing heritability. Hum Genomics 9:17.

Tuteja JH, Clough SJ, Chan WC, Vodkin LO. 2004. Tissue-specific gene silencing mediated by a naturally occurring chalcone synthase gene cluster in Glycine max. Plant Cell 16:819-835.

van Dongen HM, Masoumi N, Witwer KW, Pegtel DM. 2016. Extracellular vesicles exploit viral entry routes for cargo delivery. Microbiol Mol Biol Rev 80:369-86.

Wagschal A, Rousset E, Basavarajaiah P, Contreras X, Harwig A, Laurent-Chabalier S, Nakamura M, Chen X, Zhang K, Meziane O, Boyer F, Parrinello H, Berkhout B, Terzian C, Benkirane M, Kiernan R. 2012. Microprocessor, Setx, Xrn2, and Rrp6 co-operate to induce premature termination of transcription by RNAPII. Cell 150:1147-1157.

Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H. 2006. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev 20:1732-1743.

Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, Chiba H, Kohara Y, Kono T, Nakano T, Surani MA, Sakaki Y, Sasaki H. 2008. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453:539-543.

Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, Galas DJ, Wang K. 2010. The microRNA spectrum in 12 body fluids. Clin Chem 56:1733-1741.

Wheeler DS, Wong HR. 2007. Heat shock response and acute lung injury. Free Radic Biol Med 42:1-14.

Winter J, Jung S, Keller S, Gregory RI, Diederichs S. 2009. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11:228-234.

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. 2015. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol 33:870-876.

Witwer KW, McAlexander MA, Queen SE, Adams RJ. 2013. Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited evidence for general uptake of dietary plant xenomiRs. RNA Biol 10:1080-1086.

Witwer KW, Hirschi KD. 2014. Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary xenomiRs cross the gut and regulate genes in ingesting vertebrates, but important questions persist. Bioessays 36:394-406.

Witwer KW. 2015. Contamination or artifacts may explain reports of plant miRNAs in humans. J Nutr Biochem 26:1685.

Wong RL, Wang Q, Trevino LS, Bosland MC, Chen J, Medvedovic M, Prins GS, Kannan K, Ho SM, Walker CL. 2015. Identification of secretaglobin Scgb2a1 as a target for developmental reprogramming by BPA in the rat prostate. Epigenet 10:127-134.

Wright MW, Bruford EA. 2011. Naming ‘junk’: human non-protein coding RNA (ncRNA) gene nomenclature. Hum Genomics 5:90-98.