Task Forces
Population relevance for NTOs per EU Endocrine Disruption Criteria – Expert Group
Why?
Technical guidance is still missing in response to EU scientific criteria for the determination of endocrine disrupting (ED) properties (ECHA & EFSA, 2018), to identify whether observed ad...
Persistent chemicals and water resources protection
Background
Several initiatives end-2017 and 2018 on identification of substances of concern to drinking water resources.
ECETOC role in supporting the development of a science-based framework to...
DNEL Derivation Guidance
The ECETOC DNEL Derivation Guidance (2010) – which provides the technical underpinnings by which many/most of industry DNELs (derived no-effect levels) were developed in 2010 and post-2010 – are u...
Approaches for read-across in chemical risk assessment
Outcome
Technical Report no.109: High information content technologies in support of read-across in chemical risk assessment (Published Decempber 2010).
Read-across exploits information on struc...
Guidance on assessment factors to derive a DNEL
Outcome
In the REACH Technical Guidance Document, chapter R.8 ‘Characterisation of dose -response for human health’ proposes a tiered and systematic approach for the delineation of DNEL (and DM...
Guidance for assessing the impact of mixtures of chemicals in the aquatic environment
Outcome
The potential risk from combinations of chemicals in the environment has recently moved up the scientific, regulatory and political agenda as a result of the increasing concern about the po...
Adverse Outcome Pathways (AOPs) focusing on endocrine active chemicals
Background
There are currently many intense global activities on adverse outcome pathways (AOP). Much of this activity is focused on endocrine disruption (ED). There is a risk that AOPs will be use...
Category approaches, read-across, (Q)SAR
Health Sciences Manager Christa Hennes
Administrative Assistant Christine Yannakas
The task force completed its work in 2012; the Technical Report No. 116 can be downloaded here.
Categorisation,...
Grouping of nanomaterials
Background and Outcome
Nanomaterials and nanotechnology-enabled products have to be safe. It is imperative that they do not harm humans or the environment.
As more and more nanotechnology-enable...
Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions
Environmental Sciences Manager: Malyka Galay Burgos
Administrative Assistant Sonia Pulinckx
Background
Two ECETOC Task Forces on the risk assessment of PBTs have produced recommendations to ena...
Mode of Action and Identification of Adverse vs. Non-adverse Effects
Task Force Manager Alan Poole
Administrative Assistant Christine Yannakas
Background
The scientifically sound discrimination between adverse and non-adverse effects has always been a key elem...