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  20 January 2014

  TR 122 – Poorly Soluble Particles / Lung Overload

  SCIENCE NEWS FLASH: New ECETOC report addresses poorly soluble particles and lung overload   Brussels, January 2014 Despite being regarded as biologically inert, […]

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  • Tags : adverse outcome, Assessment, chemical composition, chemical dissolution, chronic exposure, chronic inflammation, chronic inhalation, concentration, exposed, exposure groups, exposures, Human, human risk, inflammatory, inflammatory environment, inflammatory reactions, inhalation, knowledge, lesions, lung cancer, lung overload, lung tumours, neoplastic, non-neoplastic, oxidative, particle clearance, particle retention, particles, pathological, pharmaceuticals, poorly soluble particles, primates, pulmonary effects, pulmonary inflammation, Rat, Sensitivity, threshold, Toxicity, Toxicological
• 14 January 2014

  TR 121 – Efficacy and safety of antidotes for acute poisoning by cyanides

  TR 121 : Efficacy and safety of antidotes for acute poisoning by cyanides | 19 November 2013 SCIENCE NEWS FLASH: New ECETOC report […]

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  • Tags : Acetone, acid, amygdalin, amyl nitrite, analysis, animal experiment, biological substance, blood, case report, cassava, combination, cyanide, cyanide antidote, cyanide gas, cyanide poisoning, cyanide salts, death, Dermal absorption, drug, Food, hydrocyanic, hypertension, ingestion, inhalation, neurological, nitriles, oxygen, pharmaceutica, potassium, pre-clinical antidote, pyruvate, safety, salt, smoke inhalation, SNP, sodium, sodium nitrite, sodium thiosulphate, solution, Toxicity, Treatment
• 29 December 2010

  TR 110 – Guidance on Assessment Factors to Derive a DNEL

  TR 110 : Guidance on Assessment Factors to Derive a DNEL | Dec 2010 Executive Summary The European Regulation on the Registration, Evaluation, Authorisation […]

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  • Tags : Animal, Assessment, cancer, chemical, Chemical safety assessments (CSA), chronic effects, chronic exposure, Compound, default AF, derived no-effect levels (DNEL), exposure, exposure scenarios (ES), Food, general population, health, Informed AF, inhalation, irritation, local effect, Lung, R.8 guidance, REACh, REACH TGD, safety assessment, skin contact, systemic effect, targeted risk assessment (TRA), Treatment, workplace
• 28 September 2007

  JACC Report 53 – Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin vol.II

  JACC 053 Vol II : Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin (CAS No. 74-90-8, 143-33-9, 151-50-8 and 75-86-5), Volumes I […]

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  • Tags : 1 1-dichloroethylene, 1 1-Difluoroethane, Acute toxicity, adrenaline, Allergy, American Industrial Hygiene Association, Ames test, Aquatic organisms, Atmospheric degradation, BHK21, Cardiac sensitisation, Chlorofluorocarbon, chromatography, chromosomal aberration, CO2, developmental toxicity, Ecotoxicity, environment, environmental toxicity, exposure, flammable colourless gas, formaldehyde, Genomics, genotoxic potential, global warming potential, HF, HFC, HFC-143a, Human volunteers, in vitro, in vivo, inhalation, lymphocytes, metabolite, method of exposure, NOAEL, occupational exposure., Ozone depletion, PAFT, physico-chemical properties, rabbit, rats, Refrigeration systems, reproductive effects, Salmonella typhimurium, Sex, stratospheric ozone layer, Styles Assay, testicular weight, Toxicity, Toxicology, trifluoroacetaldehyde, Trifluoroethane, Trifluoroethanol, volatilise, whole-body
• 28 September 2007

  JACC Report 53 – Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin vol.I

  JACC 053 Vol I : Cyanides of Hydrogen, Sodium and Potassium, and Acetone Cyanohydrin (CAS No. 74-90-8, 143-33-9, 151-50-8 and 75-86-5), Volumes I […]

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  • Tags : 1 1-dichloroethylene, 1 1-Difluoroethane, Acute toxicity, adrenaline, Allergy, American Industrial Hygiene Association, Ames test, Aquatic organisms, Atmospheric degradation, BHK21, Cardiac sensitisation, Chlorofluorocarbon, chromatography, chromosomal aberration, CO2, developmental toxicity, Ecotoxicity, environment, environmental toxicity, exposure, flammable colourless gas, formaldehyde, Genomics, genotoxic potential, global warming potential, HF, HFC-143a, Human volunteers, in vitro, in vivo, inhalation, lymphocytes, metabolite, method of exposure, NOAEL, occupational exposure., Ozone depletion, PAFT, physico-chemical properties, rabbit, rats, Refrigeration systems, reproductive effects, Salmonella typhimurium, Sex, stratospheric ozone layer, Styles Assay, testicular weight, Toxicity, Toxicology, trifluoroacetaldehyde, Trifluoroethane, Trifluoroethanol, volatilise, whole-body
• 29 October 2006

  TR 101 – Guidance for setting occupational exposure limits: Emphasis on data-poor substances

  TR 101 : Guidance for setting occupational exposure limits: Emphasis on data-poor substances | October 2006 In the absence of sound human exposure […]

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  • Tags : air concentrations, air-water partition coefficient, Animal, animal data, Carcinogenic, chemical food contaminants, chemical properties, chemical safety assessment, chemical safety report, chemical substance, chronic, concentration, distributionexpert, exposed, exposure, hazard banding, hazard categories, health, homologous, human data, hydrocarbon, inhalation, integration, Lethal, Liquid, LOAEL, mammalian, Method, MTD, mutagenic, NOAEL, NTP, Occupational exposure limit (OEL), octanol-air partition coefficient, oral, overexposure, person, procedure, progeny, protection, public health risk, REACh, read-across approach, reprotoxic, respiratory dose, risk assessor, risk phrase, scientist, sensory irritation, solid, solvent, studies, substance, targeted risk, toxic, Toxicity, Toxicological, worker, workplace
• 28 September 2006

  JACC Report 51 – Synthetic Amorphous Silica

  JACC 051 : Synthetic Amorphous Silica | September 2006 This report has been produced as part of the ECETOC Joint Assessment of Commodity […]

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  • Tags : Absorption, acute inhalation toxicity, adverse effects, agglomerates, airborne concentrations, alkali metal silicate, American Conference for Governmental Industrial Hygienists, amorphous silicas, aqueous systems, bioavailable, bone marrow, cancer, carcinogenicity, chromatography, chromosomal aberrations, chronic toxicity, Condensation, contact allergy, cosmetics, cracking, dermal irritation, dermal toxicity, developmental toxicity, diatoms, dichlorodimethyl, DNA synthesis, dryness, Ecotoxicology, elastomers, Emphysema, environment, Environmental fate, Epidemiology, Erythema, Excreted, experimental animals, eye irritant, Eye Irritation, fertility, focal fibrosis, Gas chromatography, genotoxic, Genotoxicity, granuloma, human risk assessment, Hydrophilic, hydrophobic, in vitro, in vivo, inhalable, inhalation, inks, International Agency for Research on Cancer, Intravenous injection, intrinsic toxicity, LOAEL, Long-term inhalation, long-term respiratory health effects, lung collagen, lung collagen content, lung inflammation. lung tumours, man-made SAS, mechanical irritation, methyl, mice, Morphology, mortality, mutagenic, natural flux, neoplasms, NOAEL, non-crystalline, non-toxic, oral, oral administration, particle size, peripheral, pharmaceuticals, pneumonia, precipitated silica, pulmonary function, pulmonary inflammation, pulmonary retention, pyrogenic silica, rats, reproductive organs, respirable, respiratory distress, SAS, SAS dust, Sex, Silica, silica gel, Silicon dioxide, silicon metal, Skin Irritation, sodium chloride, solubility, spectroscopy, subchronic, subcutaneously, Suffocation, surface treatment, survival rate, synthetic amorphous silica, thermal route, tissue reaction, toxic, Toxicology, tumours, weight gain, wet route
• 28 January 2006

  JACC Report 50 – 1,1,1,2-Tetrafluoroethane (HFC-134a) Second edition

  JACC 050 : 1,1,1,2-Tetrafluoroethane (HFC-134a) (CAS No. 811-97-2) (Second Edition) | January 2006 This report has been produced as part of the ECETOC […]

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  • Tags : 1 1 1 2-Tetrafluoroethane, Acute toxicity, adrenaline, adverse effects, air-conditioning, aquatic environment, Aquatic organisms, atmospheric concentration, Atmospheric degradation, atmospheric lifetime, bioaccumulation, biodegradation, biota, body weight gain, bromine, carbon dioxide, Cardiac sensitisation, cell adenoma, chemical, chemical properties, chlorine, Chlorofluorocarbon, chronic toxicity, control groups, corn oil, degradation, DNA synthesis, Ecotoxicity, environment, Environmental fate, Epinephrine, experimental animals, expired air, Eye Irritation, female rats, fertility, formic acid, gas, genotoxic, global warming potential, greenhouse effect, haematology, HFC-134a, hydrochlorofluorocarbons, hydrofluoric acid, hydroxyl radicals, hyperplasia, in vitro, in vivo, inhalation, irritation, male rats, Metabolism, metered dose inhalers, non flammable gas, non-neoplastic, occupational exposure., Ozone depletion, PAFT, partition, Programme for Alternative Fluorocarbon Toxicity Testing, Propellants, rats, Refrigeration, reproductive effects, Sex, Skin Irritation, Skin sensitisation, skin sensitiser, soil, sorption, spectroscopy, teratogenic, testicular Leydig, testicular Leydig cell hyperplasia, testosterone, Toxicity, trifluoroacetic acid, Troposphere, tumours