Assessment

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  20 January 2014

  TR 122 – Poorly Soluble Particles / Lung Overload

  SCIENCE NEWS FLASH: New ECETOC report addresses poorly soluble particles and lung overload   Brussels, January 2014 Despite being regarded as biologically inert, […]

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  • Tags : adverse outcome, Assessment, chemical composition, chemical dissolution, chronic exposure, chronic inflammation, chronic inhalation, concentration, exposed, exposure groups, exposures, Human, human risk, inflammatory, inflammatory environment, inflammatory reactions, inhalation, knowledge, lesions, lung cancer, lung overload, lung tumours, neoplastic, non-neoplastic, oxidative, particle clearance, particle retention, particles, pathological, pharmaceuticals, poorly soluble particles, primates, pulmonary effects, pulmonary inflammation, Rat, Sensitivity, threshold, Toxicity, Toxicological
• 26 June 2013

  TR 119 – Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals

  TR 119 : Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals | 26 March 2013 Technical Report no.119. Evaluation of systemic […]

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  • Tags : (Q)SAR, ADME, Animal, Assessment, assessment tool, chemical safety, Chemicals, decision tree, derivation, dermal, Dermal absorption, dermal risk, exposure, Exposure assessment, initial risk characterization, legislation, non-animal, paint, pharmaceuticals, REACh, refined risk characterization, risk assesment, safety, studies, Toxicology
• 21 November 2012

  TR 116 – Category approaches, read-across, (Q)SAR

  TR 116 : Category approaches, read-across, (Q)SAR | 21 November 2012 Background An accepted practice for the assessment of human health and environmental […]

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  • Tags : (Q)SAR, analogue, approach, Assessment, category, Ecotoxicity, environmental, experimental, expert, generic, in vitro, in vivo test, Industry, mammalian, metal, narcotic, non-testing approach, organic, PBPK, product, REACh, read-across, Risk assessment, safety, skin, studies, target chemicals, toxic, Toxicity
• 29 October 2011

  TR 112 – Refined Approaches for Risk Assessment of PBT/vPvB Chemicals

  TR 112 : Refined Approaches for Risk Assessment of PBT/vPvB Chemicals | October 2011 ISSN-0773-8072-112 (print) ISSN-2079-1526-112 (online) D-2011-3001-218 Summary Building upon a […]

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  • Tags : Assessment, Biomonitoring, chemical, Critical body burden approach (CBB), Ecological, environmental, Environmental exposure concentration (PEC), exposure, Exposure assessment, Food, food chain, Hazard, Kinetic, Methodology, Modelling technique, PBT chemicals, PBT/vPvB chemicals, Physico-chemical, PNEC, Predicted no effects concentration (PNEC), RAIDAR, Research, Risk assessment, Scientific, Secondary poisoning, substance, Toxicity, Toxicological, Uncertainty, Value
• 29 December 2010

  TR 110 – Guidance on Assessment Factors to Derive a DNEL

  TR 110 : Guidance on Assessment Factors to Derive a DNEL | Dec 2010 Executive Summary The European Regulation on the Registration, Evaluation, Authorisation […]

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  • Tags : Animal, Assessment, cancer, chemical, Chemical safety assessments (CSA), chronic effects, chronic exposure, Compound, default AF, derived no-effect levels (DNEL), exposure, exposure scenarios (ES), Food, general population, health, Informed AF, inhalation, irritation, local effect, Lung, R.8 guidance, REACh, REACH TGD, safety assessment, skin contact, systemic effect, targeted risk assessment (TRA), Treatment, workplace
• 29 December 2007

  TR 102 – Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals

  TR 102 : Intelligent Testing Strategies in Ecotoxicology: Mode of Action Approach for Specifically Acting Chemicals | December 2007 There is widespread regulatory […]

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  • Tags : Absorption, acute, Agrochemical, algae, amphibians, animal welfare, Antimycotic, aquatic, arthropod, Assessment, Bacteria, bioaccumulation, biochemical, biological, biomarker, biomedical, biomolecule, cancer, Carbamates, carrier protein, cellular, chemical, chronic, Compound, Crustaceans, CYP, cypermethrin, daphnid, development, developmental, drug, ecosystem, Ecotoxicity, environmental risk assessment (ERA), Enzyme, Ergosterol, exposure, fish, fluoxetine, Freshwater, Fungal, Growth, Homones, Human, Hydrophilic, in vivo testing, intelligent testing strategies (ITS), invertebrate, Ketoconazole, Lipophilic, mammalian, marine, Medication, microbial, microorganism, MOA, MOA1, MOA2, MOA3, MOA4, molecular, mollusks, neurotoxic, Neurotoxicity, neurotransmitter, NOEC, non-arthropod, Non-arthropods, Oestrogen, oestrogenic, organism, Pharmaceutical, pharmacological, Phylogeny, physical-chemical data, plant, Population, protein target ITS, reactive chemicals, Receptor, reproduction, reproductive, Risk assessment, science, Scientific, sensitivity ratio, serotonin, species, structure activity relationships, substance, survival, target, toxic effects, Toxicity, Toxicological, Triclosan, Tumour, vertebrate, vitellogenin, zebrafish
• 28 November 2005

  JACC Report 49 – Vinylidene Fluoride

  JACC 049 : Vinylidene Fluoride (CAS No. 75-38-7) | November 2005 This report has been produced as part of the ECETOC Joint Assessment […]

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  • Tags : Acute toxicity, American Conference of Governmental Industrial Hygienists, Assessment, atmosphere, Atmospheric degradation, bioaccumulation, biodegradation, biomagnification, body weight, breakdown, carbon dioxide, Carbonyl fluoride, Cardiac sensitisation, chlorotrifluoroethylene, citric acid cycle, clinical chemistry, colourless odourless flammable gas, copolymers, depletion, Ecotoxicity, embryotoxic, environment, Environmental fate, Environmental protection agency, EPA, exposure, Eye Irritation, fertility, fluoroacetic acid, foetotoxic, foetotoxic or teratogenic effect, food chain, formaldehyde, global warming, ground-level ozone, haematology, Hexafluoropropylene, HFC-143a, high volatility, Histopathology, hydroxyl radicals, impaired spermatogenesis, in vitro, in vivo, inhalation studies, kidneys, limited solubility, lipomas, liposarcomas, mineralisation, Mouse, NOAEL, organ weights, partition, polyvinylidene fluoride, rats, regenerative changes, reproduction, Rhinitis, Sex, soil, Soluble, stratospheric ozone, teratogenic, teratology study, Terrestrial organisms, testes, Tetrafluoroethylene, toxic, Toxicity, Troposphere, tropospheric ozone, urinary fluoride excretion, VDF, vinylidene fluoride, vomeronasal organ
• 29 December 2002

  TR 084 – Scientific Principles for Soil Hazard Assessment of Substances

  TR 084 : Scientific Principles for Soil Hazard Assessment of Substances | July 2002 This report reviews the scientific principles that should underpin […]

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  • Tags : aquatic environment, Assessment, bioaccumulation, Bioavailability, dose-response curve, Ecotoxicology, equilibrium partitioning, intrinsic toxicity, long-term effects, modifying factors, nutrient solution, soil hazard classification, surrogate data, terrestrial hazard classification, terrestrial test guidelines, toxicity classes, wastewater treatment