Human Health and Exposure Monitoring Teams

The current 2021 research portfolio under the health and exposure programme looks as follows:

  • AIMT 5.2: A computational model for neural tube closure, based on the dedicated developmental ontology constructed in the LRI AIMT-5 project, for in silico predictive toxicology of neural tube defects  Principal investigator: Aldert Piersma, RIVM, National Institute for Public Health and the Environment, The Netherlands
  • AIMT11: Enhancing in vitroDNT Testing Strategy
    Principal investigator: Ellen Fritsche, IUF, Germany
  • B 12.4: Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx)                                                                                                              Principal investigator: John Little, Virginia Tech, USA
  • B 21: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure
    Principal investigator: Katharina Schwarz, Fraunhofer ITEM, Germany
  • B 22: Tiered Methods for Quantifying Exposure to Complex Substances (“TMEx-Complex”)
    Principal investigator: Mark Parnis, Trent University, CA
  • B 23: Optimizing the benefit of REACH worker exposure assessments: ensuring meaningful health risk communication
    Principal investigator: Wouter Fransman, TNO, NL
  • C5: Integrating Multiple Molecular-level Data Streams to understand (a) range of normal adaptation vs pathology and (b) molecular generated gene expression changes and persistence over time.
    Principal investigator: Jörg Hackermüller, Helmholtz Centre for Environmental Research (UFZ), Germany
  • C6: Toxicogenomic Approaches to Support Read-Across
    Principal investigator: George Daston, Procter & Gamble, USA
  • C7: ELUMICA – Elucidating Microbial Metabolic Capacity
    Principal investigator: Saskia Sperber, BASF SE, Germany
  • C8: MATCHING – MetAbolomics ring-Trial for CHemical groupING
    Principal investigator: Mark Viant, University of Birmingham, UK
  • C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker
    Principal investigator: Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine, Germany
  • EMSG 59: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure
    Principal investigator: Aldert Piersma, RIVM, The Netherlands
  • EMSG 60: Incidence trends of selected endocrine-related diseases and conditions in Europe and North America, and the contribution of changes in human reproduction
    Principal investigator: Eva Negri, Università degli Studi di Milano, IT

For more information on the LRI,, visit their website