The current 2021 research portfolio under the health and exposure programme looks as follows:
- AIMT 5.2: A computational model for neural tube closure, based on the dedicated developmental ontology constructed in the LRI AIMT-5 project, for in silico predictive toxicology of neural tube defects Principal investigator: Aldert Piersma, RIVM, National Institute for Public Health and the Environment, The Netherlands
- AIMT11: Enhancing in vitroDNT Testing Strategy
Principal investigator: Ellen Fritsche, IUF, Germany - B 12.4: Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx) Principal investigator: John Little, Virginia Tech, USA
- B 21: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure
Principal investigator: Katharina Schwarz, Fraunhofer ITEM, Germany - B 22: Tiered Methods for Quantifying Exposure to Complex Substances (“TMEx-Complex”)
Principal investigator: Mark Parnis, Trent University, CA - B 23: Optimizing the benefit of REACH worker exposure assessments: ensuring meaningful health risk communication
Principal investigator: Wouter Fransman, TNO, NL - C5: Integrating Multiple Molecular-level Data Streams to understand (a) range of normal adaptation vs pathology and (b) molecular generated gene expression changes and persistence over time.
Principal investigator: Jörg Hackermüller, Helmholtz Centre for Environmental Research (UFZ), Germany - C6: Toxicogenomic Approaches to Support Read-Across
Principal investigator: George Daston, Procter & Gamble, USA - C7: ELUMICA – Elucidating Microbial Metabolic Capacity
Principal investigator: Saskia Sperber, BASF SE, Germany - C8: MATCHING – MetAbolomics ring-Trial for CHemical groupING
Principal investigator: Mark Viant, University of Birmingham, UK - C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker
Principal investigator: Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine, Germany - EMSG 59: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure
Principal investigator: Aldert Piersma, RIVM, The Netherlands - EMSG 60: Incidence trends of selected endocrine-related diseases and conditions in Europe and North America, and the contribution of changes in human reproduction
Principal investigator: Eva Negri, Università degli Studi di Milano, IT
For more information on the LRI,, visit their website http://www.cefic-lri.org.