2025 Annual Report
Annual Report
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends, As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
ECETOC launches Secondee Programme
News

ECETOC launches Secondee Programme

Looking for an extra challenge? A next step to help develop your career? Consider applying for our Secondee Programme! ECETOC is looking for early-career scientists currently working at a member co...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why? Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....
Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Estimating the environmental release of Synthetic Polymeric Microparticles from Products

Why? REACH restriction: SPM use restricted; emissions reporting required by May 2027. Gap: No analytical methods available to measure SPM emissions. Solution: Draft SPERC-based approac...
Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why? Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...
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Publications

Workshop Report no.36 – Microbiome Expert Workshop (Porto, 8-9 July 2019)
Workshop Report

Workshop Report no.36 – Microbiome Expert Workshop (Porto, 8-9 July 2019)

Workshop Report No. 36 April 2020 ISSN-2078-7219-036 (online)...
Technical Report no.128: Guidance on assessment and application of Adverse Outcome Pathways (AOPs) relevant to the Endocrine System
Technical Report

Technical Report no.128: Guidance on assessment and application of Adverse Outcome Pathways (AOPs) relevant to the Endocrine System

Various European chemical regulations, e.g. Regulation (EC) No. 1907/2006 (‘REACH’) and Regulation (EC) No. 1107/2009 (plant protection products) only support the marketing and use of chemical pro...
Special Report no.19: Building a Prenatal Developmental Toxicity Ontology
Special Report

Special Report no.19: Building a Prenatal Developmental Toxicity Ontology

This report discusses the need for a systematic representation of knowledge about developmental toxicity (i.e. an ontology) that would enable computer-based prediction of which chemicals are likely to...
Workshop Report no.29 – Defining the role of chemical activity in environmental risk assessment within the context of mode of action: Practical guidance and advice
Workshop Report

Workshop Report no.29 – Defining the role of chemical activity in environmental risk assessment within the context of mode of action: Practical guidance and advice

Chemical activity has recently been promoted as a useful concept for interpreting and classifying ecotoxicological data and for performing environmental risk assessment of chemicals.  The most common...
Case studies putting the decision-making framework for the grouping and 4 testing of nanomaterials (DF4nanoGrouping) into practice
Article

Case studies putting the decision-making framework for the grouping and 4 testing of nanomaterials (DF4nanoGrouping) into practice

ECETOC concept allows assessing the safety of nanomaterials  undertaking animal testing only as a very last resort Brussels, December 2015 The safety of nanomaterials can be ensured by testing...
Article

A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping)

The safety of nanomaterials can be ensured by undertaking animal testing only as a very last resort. This is the premise and promise of the Decision-making framework for the grouping and testing of na...
Article

Contribution of New Technologies to Characterisation and Prediction of Adverse Effects

Rouquié D, Heneweer M, Botham J, Ketelslegers H, Markell L, Pfister T, Steiling W, Strauss V, Hennes C. 2014. Contribution of New Technologies to Characterization and Prediction of Adverse Effects....

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