pharmaceuticals

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  17 June 2014

  TR 124 – Addendum to TR114 : Technical Basis for the TRA v3.1

  TR124: Addendum to TR114 : Technical Basis for the TRA v3.1 Newsflash: In response to feedback received from users of the TRA, ECETOC […]

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  • Tags : algorithms, Chemicals, consumer products, Ecetoc, pharmaceuticals, products, Specific Consumer Exposure Determinant (SCED), technical, TRA
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  22 January 2014

  TR 123 – Environmental risk assessment of ionisable compounds

  SCIENCE NEWS FLASH: New ECETOC report addresses environmental exposure assessment of ionisable organic compounds When predicting the concentration of an ionisable chemical in […]

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  • Tags : acetic acid, active pharmaceutical ingredients, analytical equipment, analytical methods, analytical technology, apparent chemical equilibrium concentration, Aquatic toxicity, atracurium besylate, bioaccumulation, Bioavailability, Bioconcentration, biodegradation, biodegradation test systems, bupropion hydrochloride, chemical reactivity parameters, chemical safety assessment, chemical specific kinetic data, chemical substance information, chlorpheniramine maleate, clobetasol propionate, computional methods, data retrieval systems, doxepin hydrochloride, ecotoxicilogical testing, encvironmetal risk, environment, exposure assessment tool, gemfibrozil, human and veterinary pharmaceuticals, hydolysis, ionisable chemicals, ionisable organic chemical, ionisable organic compounds, measured physical chemical property data, medicinal product, Metformin hydrochloride, multimedia models, Paroxetine hydrochloride, personal care products, pharmaceutical chemicals, pharmaceutical compounds, pharmaceutical products, pharmaceutical residues, pharmaceuticals, pharmaceuticals estrogens, physical chemical and biological properties, physical chemical hydrolysis, physical chemical property data, propranolol hydrochloride, quantative structure activity, risk assessment tools, risk management, ropinirole hydrochloride, Rosiglitazone maleate, substance property data, test protocols, testing, TGD framework, valacyclovir hydrochloride, veterinary medicinal products, veterinary pharmaceuticals, vinorelbine tartrate, wastewater treatment systems
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  20 January 2014

  TR 122 – Poorly Soluble Particles / Lung Overload

  SCIENCE NEWS FLASH: New ECETOC report addresses poorly soluble particles and lung overload   Brussels, January 2014 Despite being regarded as biologically inert, […]

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  • Tags : adverse outcome, Assessment, chemical composition, chemical dissolution, chronic exposure, chronic inflammation, chronic inhalation, concentration, exposed, exposure groups, exposures, Human, human risk, inflammatory, inflammatory environment, inflammatory reactions, inhalation, knowledge, lesions, lung cancer, lung overload, lung tumours, neoplastic, non-neoplastic, oxidative, particle clearance, particle retention, particles, pathological, pharmaceuticals, poorly soluble particles, primates, pulmonary effects, pulmonary inflammation, Rat, Sensitivity, threshold, Toxicity, Toxicological
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  13 January 2014

  TR 120 – Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions

  TR 120 : Activity-Based Relationships for Aquatic Ecotoxicology Data: Use of the Activity Approach to Strengthen MoA Predictions | 13 January 2014 Technical […]

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  • Tags : Acute toxicity, chemical activities, chemical activity, chemical concentration, chronic toxicity, equilibrium chemical potential, exposure medium, industrial chemicals, MOA, narcotic chemicals, narcotics, non-polar narcotics, pharmaceuticals, physic-chemical, regression slope, Risk assessment, slope, solubilty, soluble chemicals, species, substances, toxic effect, Toxicity, toxicity test
• 26 June 2013

  TR 119 – Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals

  TR 119 : Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals | 26 March 2013 Technical Report no.119. Evaluation of systemic […]

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  • Tags : (Q)SAR, ADME, Animal, Assessment, assessment tool, chemical safety, Chemicals, decision tree, derivation, dermal, Dermal absorption, dermal risk, exposure, Exposure assessment, initial risk characterization, legislation, non-animal, paint, pharmaceuticals, REACh, refined risk characterization, risk assesment, safety, studies, Toxicology
• 29 October 2011

  TR 111 – Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment

  TR 111 : Development of guidance for assessing the impact of mixtures of chemicals in the aquatic environment | October 2011 ISSN-0773-8072-111 (print) […]

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  • Tags : chemical, Chemical preparation, Composition, concentration, Consumer, Discharge, Ecotoxicology, Effluent, environment, environmental risk, exposure, Industrial activity, metal, Mixture, pharmaceuticals, Preparation, toxic
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  29 January 2009

  TR 104 – Framework for the Integration of Human and Animal Data in Chemical Risk Assessment

  TR 104 : Framework for the Integration of Human and Animal Data in Chemical Risk Assessment | January 2009 Human data form the […]

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  • Tags : Animal, animal data, approach, cancer, chemical, exposurchemical, exposure, Framework, health effect, human data, Human health, pharmaceuticals, Population, Risk, Risk assessment, task force, Toxicological
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  28 August 2008

  Workshop Report 12 – Workshop on Triggering and Waiving Criteria for the Extended One-Generation Reproduction Toxicity Study

  WR 12 : Workshop on Triggering and Waiving Criteria for the Extended One-Generation Reproduction Toxicity Study | August 2008 Under the new chemicals […]

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  • Tags : breakout groups, chemical safety assessment, developmental immunotoxicity, developmental neurotoxicity, DIT, DNT, Ecetoc, ECVAM, endpoints, FOB, functional observation battery, Histopathology, internal triggers, MA, motor activity, OECD, one-generation study design, PDT, PDT module, pharmaceuticals, prenatal developmental toxicity, REACh, Reproductive toxicity, reproductive toxicity study, study design, triggers
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  28 September 2006

  JACC Report 51 – Synthetic Amorphous Silica

  JACC 051 : Synthetic Amorphous Silica | September 2006 This report has been produced as part of the ECETOC Joint Assessment of Commodity […]

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  • Tags : Absorption, acute inhalation toxicity, adverse effects, agglomerates, airborne concentrations, alkali metal silicate, American Conference for Governmental Industrial Hygienists, amorphous silicas, aqueous systems, bioavailable, bone marrow, cancer, carcinogenicity, chromatography, chromosomal aberrations, chronic toxicity, Condensation, contact allergy, cosmetics, cracking, dermal irritation, dermal toxicity, developmental toxicity, diatoms, dichlorodimethyl, DNA synthesis, dryness, Ecotoxicology, elastomers, Emphysema, environment, Environmental fate, Epidemiology, Erythema, Excreted, experimental animals, eye irritant, Eye Irritation, fertility, focal fibrosis, Gas chromatography, genotoxic, Genotoxicity, granuloma, human risk assessment, Hydrophilic, hydrophobic, in vitro, in vivo, inhalable, inhalation, inks, International Agency for Research on Cancer, Intravenous injection, intrinsic toxicity, LOAEL, Long-term inhalation, long-term respiratory health effects, lung collagen, lung collagen content, lung inflammation. lung tumours, man-made SAS, mechanical irritation, methyl, mice, Morphology, mortality, mutagenic, natural flux, neoplasms, NOAEL, non-crystalline, non-toxic, oral, oral administration, particle size, peripheral, pharmaceuticals, pneumonia, precipitated silica, pulmonary function, pulmonary inflammation, pulmonary retention, pyrogenic silica, rats, reproductive organs, respirable, respiratory distress, SAS, SAS dust, Sex, Silica, silica gel, Silicon dioxide, silicon metal, Skin Irritation, sodium chloride, solubility, spectroscopy, subchronic, subcutaneously, Suffocation, surface treatment, survival rate, synthetic amorphous silica, thermal route, tissue reaction, toxic, Toxicology, tumours, weight gain, wet route