Human Health and Exposure Monitoring Teams

The LRI Health Effects Monitoring Team (HEMT) oversees LRI programme development and progress in funded research on chemical carcinogenicity, chemical allergy, neurodevelopmental disorders in children, the development of alternative approaches in mammalian toxicity testing, and new areas like epigenetics and human health effects of nanomaterials.

The current 2018 research portfolio under the health and exposure programme looks as follows*:

  • AIMT 5: Building a Prenatal Developmental Toxicity Ontology, integrating existing biological, chemical, in silico models and in vitro methods and data, aiming at an alternative integrated AOP/MoA framework for mechanistic hazard and risk assessment in developmental toxicology.
    Principal investigator: Prof. Dr. Aldert Piersma, RIVM, National Institute for Public Health and the Environment, The Netherlands
  • AIMT 7: RVis: Open Access PBPK Modelling Platform.
    Principal investigator: Dr. George Loizou, Health and Safety Laboratory (HSL), United Kingdom
  • AIMT 8: Assessing New Methodology for Repeat Dose Toxicological Hazard Assessment by “Equivalent Protection” Criteria
    Principal investigator: Dr. Sylvia Escher, Fraunhofer ITEM, Germany
  • B 15.2: Development of an integrated risk management measure library. [Extension to B15]
    Principal investigator: Dr. Wouter Fransman, TNO, The Netherlands
  • B 17: Human exposure to emerging chemicals present in the indoor environment
    Dr. Marja Lamoree, VU University Amsterdam, The Netherlands
    B 18: Database on Carcinogen Dose-response, including Information on DNA reactivity, for TTC and beyond
    Prof. Mark Cronin, Liverpool John Moores University, United Kingdom
  • B 19: Extrapolating the Applicability of Worker Exposure Measurement Data
    Principal investigator: Dr. Wouter Fransman, TNO, The Netherlands
  • B 20: Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities.
    Principal investigator: Dr. Wouter Fransman, TNO, The Netherlands
  • C 4: Towards the Development of an Omics Data Analysis Framework (ODAF) for Regulatory Application.
    Principal investigator: Dr. Florian Caiment, Maastricht University, The Netherlands
  • C 5: Integrating Multiple Molecular-level Data Streams to understand (a) range of normal adaptation vs pathology and (b) molecular generated gene expression changes and persistence over time.
    Principal investigator: Dr. Jörg Hackermüller, Helmholtz Centre for Environmental Research (UFZ), Germany
  • C 6: Omics & Read Across.
    Rfp advertised in 2017. Selection Team meeting held 13 October 2017
    Principal investigator: TBC
  • ECO 36: Paving the way for QIVIVE: from nominal to free to cellular concentrations in in vitro assays
    Principal investigator: Prof. Beate Escher, Helmholtz Centre for Environmental Research, UFZ Leipzig, Germany
  • N 5: Histopathology of rats exposed to Barium sulfate nanoparticles by life-time inhalation exposure – Effects and Biokinetics
    Principal investigator: Dr. Dirk Schaudien, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany