The LRI Health Effects Monitoring Team (HEMT) oversees LRI programme development and progress in funded research on chemical carcinogenicity, chemical allergy, neurodevelopmental disorders in children, the development of alternative approaches in mammalian toxicity testing, and new areas like epigenetics and human health effects of nanomaterials.
The current 2019 research portfolio under the health and exposure programme looks as follows*:
- AIMT 5: Building a Prenatal Developmental Toxicity Ontology, integrating existing biological, chemical, in silico models and in vitro methods and data, aiming at an alternative integrated AOP/MoA framework for mechanistic hazard and risk assessment in developmental toxicology.
Principal investigator: Prof. Dr. Aldert Piersma, RIVM, National Institute for Public Health and the Environment, The Netherlands
- AIMT 5.2: A computational model for neural tube closure, based on the dedicated developmental ontology constructed in the LRI AIMT-5 project, for in silico predictive toxicology of neural tube defects Principal investigator: Prof. Dr. Aldert Piersma, RIVM, National Institute for Public Health and the Environment, The Netherlands
- AIMT 7: RVis: Open Access PBPK Modelling Platform.
Principal investigator: Dr. George Loizou, Health and Safety Laboratory (HSL), United Kingdom
- B 12.3: Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx) Principal investigator: Dr. John Little, Virginia Tech, USA
- B 17: Human exposure to emerging chemicals present in the indoor environment
Principal Investigator: Dr. Marja Lamoree, VU University Amsterdam, The Netherlands
- B 18.2: Incorporation of repeated dose study information for non-DNA-reactive carcinogens into the CPDB database and analysis of threshold values
Principal Investigator: Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM)
- B 19.2: Refinement of a framework for extrapolating of worker exposure measurement data
Principal Investigator: Dr. Wouter Fransman, Netherlands Organisation for Applied Scientific Research (TNO)
- B 20: Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities.
Principal investigator: Dr. Wouter Fransman, TNO, The Netherlands
- B 21: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure Principal investigator: Katharina Schwarz, Fraunhofer ITEM, Germany
- C 4: Towards the Development of an Omics Data Analysis Framework (ODAF) for Regulatory Application.
Principal investigator: Dr. Florian Caiment, Maastricht University, The Netherlands
- C 5: Integrating Multiple Molecular-level Data Streams to understand (a) range of normal adaptation vs pathology and (b) molecular generated gene expression changes and persistence over time. Principal investigator: Dr. Jörg Hackermüller, Helmholtz Centre for Environmental Research (UFZ), Germany
- C 6: Toxicogenomic Approaches to Support Read-Across
Principal investigator: George Daston, Procter & Gamble, USA
- C 7: ELUMICA – Elucidating Microbial Metabolic Capacity Principal investigator: Saskia Sperber, BASF SE, Germany
- ECO 36: Paving the way for QIVIVE: from nominal to free to cellular concentrations in in vitro assays
Principal investigator: Prof. Beate Escher, Helmholtz Centre for Environmental Research, UFZ Leipzig, Germany
- EMSG 59: In Vitro Data To Parameterise PBPK Models For Inhalation Exposure Principal investigator: Aldert Piersma, RIVM, Netherlands