Objective: Take into account all available scientific tools to adequately characterise risk not only based on hazard characteristics but also on exposure data and dose-response considerations.

Current activities:

Task Force on Guidance for Classification of Reproductive Toxicants under GHS

Task Force on Targeted risk assessment

Task Force on Analysis of existing risk assessment approaches for PBT/vPvB chemicals or POPs

Task Force on Application of critical body burden in RA of SVHC

Task Force on Exploring novel ways of using SSD to establish PNECs for industrial chemicals (in preparation)

Task Force on Carcinogenicity of formaldehyde

Task Force on Cyanides antidotes

Task Force on ERA of ionisable compounds

Task Force on Linear Polydimethylsiloxanes (PDMS)

Task Force on Safety factors to derive DNELs

Workshop on Safety factors to derive DNELs (March 2010)

Joint Workshop with ILSI-HESI: Use of MoA information to improve regulatory decision making (November 2009)

Recent publications and completed activities:

Published Article: Guidance for the classification of carcinogens under GHS. Crit Rev Toxicol (2010)

Published Article: Potency values from the local lymph node assay: application to classification, labelling and risk assessment. Regul Toxicol Pharmacol (2010)

Technical Report 107: Addendum to targeted risk assessment report TR 93 (2009)

Technical Report 106: Guidance on identifying endocrine disrupting factors (2009)

Workshop Report 16: Guidance on identifying endocrine disrupting factors (2009)

Symposium at EEMS 2008: Thresholds for genotoxins in risk assessment/DNA WS Mutat Res (2009)

Workshop Report 15: Probabilistic approaches for marine risk assessment (2008)

Document  46: Potency values from the LLNA: application to classification, labelling and risk assessment (2008)

Technical Report 103: Toxicity of possible impurities and by-products in fluorocarbon products (2008)

Technical Report 102: Intelligent testing strategies in ecotoxicology: mode of action approach for specifically acting chemicals (2007)

Technical Report 98: Risk assessment of PBT chemicals (2005)

Technical Report 93: Targeted risk assessment (2004)

Technical Report 92: Soil and sediment risk assessment (2004)

Workshop Report 02: Workshop on EQS and WFD versus PNEC and REACH - Are they doing the job? (2004)