Objective: Ensure that the methods and the testing strategy to identify and characterise developmental and reproductive toxicants are appropriate and optimised.

Current activities:

• Task Force on Guidance for classification of reproductive toxicants under GHS
• Monitoring of an LRI project: Evaluation of signal transduction pathways in model organisms as critical indicators of developmental toxicity
• Monitoring of an LRI project: Characterisation of testicular toxicity using traditional and omic tools
• Monitoring of an LRI project: Reprogramming of DNA methylation during mammalian development and environmental impact of endocrine disruptors
• ECETOC Representation in the (former) ECB Expert Group on reproduction toxicity potency

Recent publications and completed activities:

• Technical Report 106: Guidance on interpreting endocrine disrupting effects (2009)
• Workshop Report 16: Guidance on interpreting endocrine disrupting effects (2009)
• Published Article: A modular approach to the extended one-generation reproduction toxicity study. ATLA (2009)
• Workshop Report 12: Triggering/waiving criteria for the extended one-generation reproduction toxicity studies (2008)
• Document 45: Triggering/waiving criteria for the extended one-generation reproduction toxicity studies (2008)
• Workshop Report 04: Influence of maternal toxicity in studies on developmental toxicity (2004)
• Monograph 31: Guidance on evaluation of reproductive toxicity data (2002)