DOC 030 – Comments and Proposed Changes to OECD Screenings Information Data Set Draft Test Guidelines “Preliminary reproduction Toxicity Sreening Test” and “Combined Repead Dose and Reproductive / Developmental Toxicity Screen Test”

Abstract

DOC 030 : Comments and Proposed Changes to OECD Screenings Information Data Set Draft Guidelines | July 1992

In the OECD Existing Chemicals Programme a Screening Information Data Set (SIDS) has been defined. In this connection two experimental guidelines have been written, a ?Preliminary Reproduction Toxicity Screening Test? and a ?Combined Repeat Dose and Reproductive/Developmental Screening Test.? The former has advantages in providing information relatively quickly compared with conventional reproduction studies. The latter tries to evaluate target organ and reproduction toxicity within the same study and these two aims are not compatible in terms of doses required to investigate these two forms of toxicity. The guidelines have been reviewed and recommendations for change are made.