ECETOC Workshop on Applying ‘Omics Technologies in Chemicals Risk Assessment

10-12 October, 2016
NH Eurobuilding Hotel
Madrid, Spain

Objectives

  1. With representatives from European Commission; the OECD; US-EPA; US-FDA – share and update frameworks developed by ECETOC multi-expert teams on how to aquire, analyse and apply ‘omics data. Ensue fitness for purpose.
  1. Generate consensus of opinion on the steps needed to achieve best practices for applying ‘omics technologies in chemicals risk assessment.

Topics covered (Room Documents distributed prior to the workshop):

  • Establishing GLP-like Context for Collecting, Storing and Curating ‘Omics Data
  • Best Practices for Analysisng ‘Omics Data
  • Best Practices for WoE Approaches for Integrating ‘Omics Data
  • Best Practices for Establishing Pathways to Connect Results of ‘Omic Data to Phenotype

Context

’Omics technologies hold the promise of generating detailed information faster, more accurately and easier than ever before. These emerging technologies could help:

  • Reduce animal testing, with the ultimate goal of replacing animal testing altogether
  • Increase the number of chemicals that can be accurately and efficiently tested in a given time
  • Identify new and emerging risks through toxicological screening and reliable biomarkers

Yet current methodological and analytical uncertainties limit the application of ‘omics technologies. Best practice for acquiring, analysing and applying ‘omics data is needed so that information from ‘omics can be reliably verified and confidently integrated into regulatory risk assessment.


Organising Committee

Jim Bridges, University of Surrey, UK
Tim Gant, CRCE, UK
Madeleine Laffont, ECETOC, Belgium
Mark Pemberton, Systox, UK
Alan Poole, ECETOC, Belgium
Weida Tong, NCTR/FDA, USA
Ben van Ravenzwaay, BASF, Germany


Programme

omics-ws_programme_participants-list_biogs_abst_oct-2016-madrid


Presentations

00_cover-slide

01_alan-poole

02_eeva-leinala_oecd-ecetoc-omics-oct-2016

03_matt-martin_opening-session

04_aldert-piesma

05_ttralau_madrid2016_pdf_for_upload

06_andrew-worth_ecetoc_10-10-16

07_weida-tong_2016-reproducibletgx_ecetoc-v2

08_ben-van-ravenzwaay_intro

09_hans-martin-kauffmann_presentation-ecetoc-workshop-10oct16

10-ben-van-ravenzwaay

11_amber-goetz_glp_madrid-2016

12_david-rouquie_qpcr-process

13_madeleine-laffont

15_madeleine-laffont

16_alan-poole

17a_mark-pemberton-quantitative-weight-of-evidence

17b_jim-bridges-omics-qwoe

17 Video version of Mark Pemberton’s and Jim Bridges’ presentations: https://youtu.be/f_i8Lg-VPtc

18_amber-goetz_mouse-liver-tumor

19_madeleine-laffont

21_alan-poole

23_kamin-johnson_ecetoc-conf_using-omics-in-chemical-risk-assessment

28_applying-technology-ra-tim-gant_seitz

30_tim-ebbels-161012-ecetoc-madrid


Publications following the Workshop

13 September 2017

A set of 5 papers have been accepted for publication in Regulatory Toxicology and Pharmacology – further details will be added here shortly

Responses Inquiry 2016 Regulatory Use Omics Data

 

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