ECETOC Task Force on Poorly Soluble Particle / Lung Overload meeting

When Wednesday, 6 Mar 2013

Where ECETOC Offices, Brussels, Belgium (map)

Description 

Meeting for task force members only

The majority of data on respiratory effects of inhaled poorly soluble particles (PSP) stems from rat inhalation studies. This relates to the rat-specific effect pattern of ‘lung overload’ for the inhalation toxicity of PSP. The relevance of the rat as a model for the assessment of repeated exposure to PSP for humans has been questioned by a number of analyses since the rat was shown to be particular sensitive towards these effects compared to other rodents, non-human primates and humans. The last comprehensive review was developed in the year 2000 by the ILSI Risk Sciences Institute. Although the ‘lung overload’ phenomena is known for a long time, it has recently become more prominent for the derivation of DNEL under REACH registrations, setting of exposure limits, and for classification and labelling under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) . The United Nations Sub-Committee of Experts on GHS in 2009 requested further input has been requested from industry.

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